Is a South Asian Calorie-Restricted Diet Effective for Weight Loss in Young Adults?
An RCT finds a culturally tailored South Asian calorie-restriction diet produces modest short-term weight loss in young adults. PICO summary and expert commentary.
Nutrition & Lifestyle
Diet, physical activity, behavioural and lifestyle interventions for metabolic and endocrine health.
Does Apolipoprotein E Genotype Affect Flaxseed Oil Response in Type 2 Diabetes?
A small RCT finds flaxseed oil reduces platelet aggregability but not other risk markers in type 2 diabetes, with no ApoE genotype effect. PICO summary and expert commentary.
Is a Low-Intensity Diet Program for Gestational Diabetes Effective Across Cultures?
A feasibility analysis finds a culturally tailored dietary intervention engages diverse women with gestational diabetes equally, but does not change measured intake. PICO summary and commentary.
Does a Preconception Lifestyle Change Improve Newborn Outcomes in Those at Risk for Gestational Diabetes?
A secondary analysis of the BEFORE THE BEGINNING trial finds preconception lifestyle change does not reduce macrosomia or neonatal adiposity. PICO summary and expert commentary.
Look AHEAD: Intensive Lifestyle Intervention Does Not Reduce Cardiovascular Events in Obese Type 2 Diabetes
The Look AHEAD trial demonstrated that intensive lifestyle intervention targeting weight loss in overweight or obese adults with type 2 diabetes did not reduce cardiovascular events over 9.6 years despite clear differences in weight, fitness, and glycaemic control, establishing a critical negative result that informed the rationale for pharmacological obesity treatment with greater weight loss efficacy.
Can Exercise and Polyphenol Supplements Together Improve Prediabetes?
A four-arm RCT finds combining training with a polyphenol supplement improves prediabetes markers most, with exercise the main driver. PICO summary and expert commentary.
Can AntiAGE-Biom Probiotic Improve Metabolism in Type 2 Diabetes?
An RCT finds the AntiAGE-Biom probiotic does not lower HbA1c but shows a subgroup body-composition signal in type 2 diabetes. PICO summary and expert commentary.
Can the Chester Step Test Help Personalize Exercise for Type 2 Diabetes?
An RCT finds Chester Step Test-guided post-dinner exercise lowers postprandial glucose and variability in type 2 diabetes on exercise days. PICO summary and expert commentary.
Who Was Less Likely to Join a Diabetes Exercise Trial?
A recruitment analysis finds men, Hispanics, and Spanish speakers underenrol at every step of a diabetes exercise trial despite active outreach. PICO summary and commentary.
Can Beetroot Supplements Improve Heart Health in CAD Patients?
A secondary analysis finds beetroot supplements improve fatty acid and oxidant markers in coronary artery disease, but only short-term surrogates. PICO summary and commentary.