Diet, physical activity, behavioural and lifestyle interventions for metabolic and endocrine health.
A secondary analysis of a weight-loss-maintenance RCT found that low-calorie-diet weight loss raised serum 25(OH)D in both sexes, but further loss and low baseline vitamin D tracked with maintenance only in women. PICO summary and expert commentary.
Two small crossover trials in adults with type 1 diabetes found neither protein source nor carbohydrate glycaemic index significantly altered postprandial glucose. PICO summary and expert commentary.
A 253-adult randomized trial found that 25% calorie restriction produced consistent enteropancreatic hormone shifts across diet patterns, and that larger shifts were associated with more weight regain afterwards. PICO summary and expert commentary.
A manufacturer-sponsored randomized trial of a low-glycemic-index/slow-digesting carbohydrate product in obese pregnant women found no effect on the primary glycemic outcomes. PICO summary and expert commentary.
The ARIADNE non-inferiority trial tested whether a supported total diet replacement programme worsened eating disorder symptoms in adults with type 2 diabetes at high risk. PICO summary and expert commentary.
A double-blind RCT testing whether the Omentin-1 Val109Asp genotype modifies vitamin D's effects on HDL-C, insulin resistance and abdominal obesity in prediabetic women. PICO summary and expert commentary.
A LIFE-Moms secondary analysis finds maternal metabolic phenotype drives gestational diabetes and infant adiposity beyond weight gain, with similar treatment response. PICO summary and commentary.
A randomised trial finds a self-management programme improves social quality-of-life domains, but not general health, in obese patients awaiting joint replacement. PICO summary and commentary.
An RCT finds reducing sitting did not help metabolic flexibility overall, but those cutting at least 30 minutes a day of sitting improved it. PICO summary and commentary.
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