Endocrinology
Levothyroxine vs LT4-LT3 After Thyroidectomy: A Feasibility Trial
A 24-week double-blind feasibility trial (n=12) found LT4 monotherapy did not normalize free T4 and total T3 after thyroidectomy while LT4-LT3 did, but weight and cholesterol differences were non-significant. PICO summary and expert commentary.
Does TransCon PTH (Palopegteriparatide) Improve Outcomes in Adults With Hypoparathyroidism?
The phase 3 PaTHway trial finds TransCon PTH frees most adults with hypoparathyroidism from conventional therapy and halves urinary calcium. PICO summary and expert commentary.
rhTSH Non-Inferior to Thyroid Hormone Withdrawal for Radioactive Iodine Ablation in Intermediate-Risk Thyroid Cancer: RCT
A phase 3 trial finds recombinant human TSH non-inferior to thyroid hormone withdrawal for radioiodine ablation in intermediate-risk thyroid cancer, with fewer adverse events. PICO summary and commentary.
rhTSH Noninferior to Hormone Withdrawal for RAI Ablation in Intermediate-Risk Thyroid Cancer
An open-label phase 3 noninferiority trial finds recombinant human thyrotropin matches thyroid hormone withdrawal for radioactive iodine ablation success in intermediate-risk differentiated thyroid cancer, with fewer adverse events. PICO summary and expert commentary.
Prolonged Sleep Restriction Reduces TSH Levels in Healthy Women: Pooled RCT Analysis
Pooled RCTs find mild sleep restriction lowers TSH in women specifically, with no effect overall and no change in FT4. PICO summary and expert commentary.