Summary:
In patients with non-infected diabetic foot ulcers, photobiomodulation (PBM) therapy at 660 nm with energy densities of 4, 8, and 12 J/cm² significantly reduced ulcer area over a 10-week period compared to control treatment using 904 nm GaAs laser with 10 J/cm², though it was associated with a lower proportion of responders at the 4 J/cm² dose.
| PICO | Description |
|---|---|
| Population | Patients with non-infected diabetic foot ulcers undergoing standard wound care. |
| Intervention | Photobiomodulation therapy using HeNe laser at 660 nm, 20 mW, continuous mode, administered twice weekly for 10 weeks at energy densities of 4, 8, or 12 J/cm². |
| Comparison | Control group received infrared photobiomodulation using GaAs laser at 904 nm, 70 mW, at an energy density of 10 J/cm², also twice weekly for 10 weeks. |
| Outcome | All groups experienced significant ulcer size reduction over 10 weeks (p < 0.0001); no statistically significant difference between groups at 5 or 10 weeks. Best response observed with energy densities ≥8 J/cm²; 4 J/cm² had fewer responders. |
Source: Mariana Bezerra Miranda, et al. “Dose-response and efficacy of 660-nanometer low-level laser therapy in healing diabetic foot ulcers: a randomized, double-blind, clinical trial.” Read article here.
