Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
A small single-centre study found that adding a long-acting GLP-1 receptor agonist to metformin lowered BMI but did not show a significant between-group glycaemic advantage. PICO summary and expert commentary.
Secondary analysis of the SELECT trial: semaglutide 2.4 mg increased regression to normoglycaemia and reduced progression to diabetes in adults with overweight or obesity and cardiovascular disease, yet did not slow glycaemic progression over time. PICO summary and expert commentary.
How patient and public involvement shaped the design of ASCEND PLUS, a decentralised RCT of oral semaglutide for cardiovascular prevention in type 2 diabetes. PICO summary and expert commentary.
A 32-week post hoc MRI substudy of 80 patients with type 2 diabetes finds semaglutide and empagliflozin each reduce cortical ADC and total kidney volume, with combination therapy lowering kidney volume most. PICO summary and expert commentary.
PIONEER 12 was a 26-week, double-blind, manufacturer-sponsored Phase IIIa trial showing oral semaglutide lowered HbA1c and body weight more than sitagliptin in a predominantly Chinese population with type 2 diabetes. PICO summary and expert commentary.
PIONEER 11, a 26-week Phase IIIa trial, found oral semaglutide monotherapy lowered HbA1c across all doses and reduced body weight at 7 mg and 14 mg versus placebo in a predominantly Chinese type 2 diabetes population. PICO summary and expert commentary.
STEP 10 randomised phase 3 trial of once-weekly semaglutide 2.4 mg versus placebo in adults with obesity and prediabetes: greater weight loss and reversion to normoglycaemia at 52 weeks. PICO summary and expert commentary.
A 12-week pilot randomised trial in 30 adults with type 2 diabetes compared a very-low calorie diet, semaglutide, and their combination on weight, body composition, and beta-cell function. PICO summary and expert commentary.
In the FLOW randomised controlled trial, weekly semaglutide reduced major kidney disease events and cardiovascular death in patients with type 2 diabetes and chronic kidney disease. PICO summary and expert commentary.
A prespecified FLOW subgroup analysis tested whether semaglutide's kidney and cardiovascular benefit held with or without baseline SGLT2 inhibitor use in type 2 diabetes and CKD. PICO summary and expert commentary.
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