An ex-vivo study finds early empagliflozin dampens NLRP3 inflammasome activity in macrophages from post-MI diabetic patients, a mechanistic signal. PICO summary and commentary.
Browsing: Cardiovascular Outcomes
A secondary analysis of the LeIKD trial finds longer endurance-exercise duration, more than intensity, improves fitness in older patients with coronary heart disease and type 2 diabetes, with early engagement predicting adherence. PICO summary and commentary.
The ABILITY Diabetes Global trial finds the Abluminus DES+ stent fails non-inferiority to the XIENCE everolimus-eluting stent in diabetes, with higher repeat revascularisation and target-lesion failure. PICO summary and commentary.
Summary: In Chinese middle-aged and elderly adults with prediabetes or early diabetes, purified anthocyanin supplementation (160, 320, and 640 mg/day…
A 12-week dose-response trial finds purified anthocyanin supplements up to 640 mg/day do not improve arterial stiffness, blood pressure, or cardiovascular risk in older adults with high blood sugar. PICO summary and commentary.
Summary: In individuals at risk for dementia with cardiometabolic features, intentional, non-pharmacological weight loss significantly reduced dementia risk as detected…
An observational ACCORD analysis finds higher weight-adjusted waist index is independently associated with more cardiovascular events, heart failure, and mortality in type 2 diabetes, outperforming BMI. PICO summary and commentary.
The SURPASS-CVOT trial finds tirzepatide noninferior but not superior to dulaglutide for major cardiovascular events in type 2 diabetes, confirming both incretin therapies are cardioprotective. PICO summary and commentary.
A prespecified SELECT analysis finds semaglutide’s cardiovascular benefit is largely independent of weight loss, with only a third mediated by waist reduction. PICO summary and commentary.
A TALOS-AMI post hoc analysis finds switching from ticagrelor to clopidogrel a month after MI is consistent across diabetes status, though within-diabetes bleeding and ischemic differences were not significant. PICO summary and commentary.