A secondary analysis of the CORDIOPREV trial reports that a lower baseline neutrophil count is associated with type 2 diabetes remission in patients with coronary heart disease following a Mediterranean diet. PICO summary and expert commentary.
Author: Hormone Insight Editorial Team
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A within-trial economic evaluation of the CIC-PDD integrated care model for type 2 diabetes with depressive symptoms reports a cost per QALY around $7,400 to $7,900. PICO summary and expert commentary.
A randomized crossover trial in 75 young adults found acute sucralose raised hypothalamic blood flow and, versus sucrose, increased hunger, with no hunger difference versus water. PICO summary and expert commentary.
DIAMONDS is a published protocol for a randomised trial testing a supported diabetes self-management programme in adults with type 2 diabetes and severe mental illness; no results are reported yet. PICO summary and expert commentary.
Summary: In 70 Iranian women with newly diagnosed PCOS (aged 15–40 years), 330 mg of Salvia officinalis extract daily for eight weeks significantly reduced triglycerides and malondialdehyde compared with placebo, with significant favourable mean changes also seen in HDL cholesterol and total antioxidant capacity. Other lipid parameters (LDL cholesterol, total cholesterol) were unchanged. The extract was positioned as a potential adjunctive therapy for the metabolic and oxidative dimensions of PCOS rather than a replacement for conventional care. PICO Summary ElementDetailPopulation70 Iranian married women aged 15–40 years with newly diagnosed PCOS.InterventionSalvia officinalis (sage) extract 330 mg daily for 8 weeks.ComparisonMatching placebo…
A 3-month randomised controlled trial found that a 10-hour time-restricted eating window did not alter mitochondrial bioenergetics in blood cells of adults at high type 2 diabetes risk. PICO summary and expert commentary.
A 24-week double-blind feasibility trial (n=12) found LT4 monotherapy did not normalize free T4 and total T3 after thyroidectomy while LT4-LT3 did, but weight and cholesterol differences were non-significant. PICO summary and expert commentary.
A decentralized n-of-1 crossover trial found dapagliflozin lowered the urine albumin-to-creatinine ratio by 15.1% versus placebo over 1-week periods in 20 adults with type 2 diabetes, while demonstrating reliable remote sampling. PICO summary and expert commentary.
A 2-year cluster RCT in India found a family-based, health-worker-delivered programme cut adult body weight by an adjusted 2.61 kg versus enhanced usual care. PICO summary and expert commentary.
A secondary analysis of the EARLIER trial found that diabetes plus CKD predicted worse cardiovascular outcomes in acute heart failure, while eplerenone’s effects appeared consistent across subgroups. PICO summary and expert commentary.