Hormone Insight Editorial Team

Can Diet and Metformin Improve Prediabetes?

A crossover trial finds a moderate-FODMAP diet plus metformin lowers postprandial glucose and raises GLP-1 in prediabetes, with microbiota shifts. PICO summary and commentary.

Is Dapagliflozin Safe in Hospitalised COVID-19 Patients With and Without Type 2 Diabetes?

A prespecified DARE-19 analysis found dapagliflozin was safe and well tolerated in hospitalised COVID-19 patients regardless of type 2 diabetes status, with no demonstrated efficacy benefit. PICO summary and expert commentary.

Should Diabetic Patients Take Antibiotics After a Simple Tooth Extraction?

Which Add-On Works Better: Empagliflozin or Sitagliptin?

A double-blind RCT finds empagliflozin gives broader cardiometabolic benefit than sitagliptin or metformin as add-on therapy in type 2 diabetes. PICO summary and commentary.

Can Gum Treatment Improve Oral Health in Older Adults with Type 2 Diabetes?

An RCT finds a periodontal health programme improves oral hygiene and knowledge in older diabetic patients, but not oral-health quality of life. PICO summary and commentary.

What Affects Gum Treatment Success in Diabetes?

A machine-learning analysis finds lower baseline periodontal severity and HbA1c predict better response to gum therapy in diabetes (random forest AUC 0.83). PICO summary and commentary.

Does Dapagliflozin Improve Heart Outcomes After a Heart Attack?

A DAPA-MI subanalysis finds dapagliflozin reduces new-onset diabetes after heart attack regardless of glucose or BMI, with most symptom benefit in prediabetes. PICO summary and commentary.

Can CBT for Diet Improve Glucose and Pregnancy Outcomes in Gestational Diabetes?

A multicentre RCT finds a CBT-based dietary app improves postprandial glucose and reduces macrosomia in gestational diabetes. PICO summary and commentary.

Does Real-Time Glucose Monitoring Help in Gestational Diabetes?

Can Home Exercise Improve Brain Function and Inflammation in Diabetic Postmenopausal Women?

An RCT finds home dual-task exercise improves executive function and HDL in diabetic postmenopausal women, but does not change the TNF/IL-10 balance or glucose. PICO summary and commentary.