Summary:In type 2 diabetic patients undergoing single simple dental extractions, amoxicillin did not significantly reduce the risk of alveolar osteitis, infection, or delayed healing compared to placebo, and its use is considered unnecessary when managing these cases.
Source: Matias Garcia-Blanco, et al. “Randomized controlled trial comparing antibiotics to placebo for single simple dental extractions in diabetic patients.” Read article here.
| PICO | Description |
|---|---|
| Population | Patients with type 2 diabetes undergoing single simple dental extractions. |
| Intervention | Administration of 500 mg amoxicillin. |
| Comparison | Placebo treatment. |
| Outcome | No significant differences were observed for alveolar osteitis, infections, or healing delays between groups. The study suggests that antibiotic use in these cases may not be necessary. |
RCT
Acta Odontol Latinoam · 2025
Amoxicillin vs placebo for diabetic tooth extractions
RCT · type 2 diabetes · 14 days
Trial design
Proportion reaching endpoint
Alveolar osteitis
0% vs 0%
No cases either arm
Infection
0% vs 0%
Local or systemic
Delayed healing
NS
No difference at 7 d
Analgesics used
More on amoxicillin
p<0.05
⬡ Bottom Line
No alveolar osteitis or infection occurred in either arm after simple extractions in controlled type 2 diabetics. Amoxicillin gave no benefit and was linked to more analgesic use, so routine prophylaxis appears unnecessary.
P
Population
Controlled type 2 diabetics needing a single simple non-impacted extraction (n=56)
I
Intervention
Pre-operative amoxicillin 500 mg
C
Comparator
Pre-operative placebo
O
Outcome
Alveolar osteitis, local or systemic infection, delayed healing
