Summary: In individuals with overweight or obesity, tirzepatide treatment significantly improved weight reduction (≥5%) compared to baseline and early non-responders, though it was associated with potential gastrointestinal side effects. PICO Description Population Adults with overweight or obesity participating in the SURMOUNT-1 trial and categorized as late responders to tirzepatide. Intervention Tirzepatide administration (5 mg, 10 mg, or 15 mg doses) over an extended treatment period exceeding 12 weeks. Comparison Response was compared to weight reduction outcomes observed at 12 weeks (early response) and baseline. Outcome 90% of late responders to tirzepatide achieved ≥5% weight reduction by Week 72, surpassing early…
Author: FWA
Summary: In adults with type 2 diabetes, high-phenolic extra virgin olive oil (EVOO) from native Galician olives significantly improved glycemic control and secondary outcomes (lipid profiles, anthropometric measures, and blood pressure) compared to a control group consuming standard olive oil, though it was associated with minor gastrointestinal side effects. PICO Description Population Adults with type 2 diabetes undergoing long-term dietary intervention. Intervention Consumption of high-phenolic extra virgin olive oil (EVOO) derived from native Galician olives. Comparison Consumption of standard olive oil with lower phenolic content. Outcome The high-phenolic EVOO group demonstrated improvements in glycemic control (HbA1c levels), enhanced lipid profile,…
Summary: In individuals with diabetes using the Omnipod 5 automated insulin delivery system, activation of the Activity feature prior to exercise significantly reduced insulin delivery and attenuated glucose drops compared to the Auto mode (without the Activity feature), though hypoglycemia incidence was similar across all conditions. These findings suggest the importance of using additional strategies, such as earlier activation of the Activity feature and/or carbohydrate intake, to further mitigate hypoglycemia risk during exercise. PICO Description Population Individuals with diabetes using the Omnipod 5 automated insulin delivery system during exercise. Intervention Activation of the Omnipod 5 Activity feature either 30 or…
Structured Summary: In patients with type 2 diabetes suffering from diabetic peripheral neuropathy (DPN), nanocurcumin supplementation did not significantly improve pain, neuropathic outcomes, metabolic, or cardiovascular parameters compared to placebo, though it was associated with no significant adverse effects. PICO Description Population Patients with type 2 diabetes suffering from diabetic peripheral neuropathy. Intervention Daily nanocurcumin supplementation over 16 weeks. Comparison Placebo. Outcome Over 16 weeks, nanocurcumin did not improve pain levels, neuropathy scoring, or metabolic and cardiovascular parameters compared to placebo. It was well tolerated without significant adverse effects reported. Source: Mansour, Asieh, et al. “The effectiveness and safety of…
Summary: In patients with diabetic peripheral neuropathy (DPN), once-daily prolonged-release (PR) pregabalin significantly improved pain management compared to placebo and was comparable to immediate-release (IR) pregabalin, though it was associated with common side effects like dizziness and somnolence. PICO Description Population Patients with diabetic peripheral neuropathy experiencing moderate to severe pain. Intervention Once-daily prolonged-release pregabalin (150–600 mg/day). Comparison Placebo and immediate-release pregabalin (thrice-daily doses of 150–600 mg/day). Outcome Pregabalin PR had comparable efficacy to pregabalin IR in managing pain and significantly improved outcomes compared to placebo. Common side effects included dizziness and somnolence. Source: Shilpi Dhawan, et al. “Efficacy and…
Summary: In patients with type 2 diabetes in underserved communities, an adaptive mHealth intervention showed no significant changes in patient-provider communication compared to control groups receiving standard interventions ,though it was associated with increased accessibility for underserved populations. PICO Description Population Patients with type 2 diabetes, particularly from underserved communities. Intervention Adaptive mHealth intervention designed to improve patient-provider communication. Comparison Standard interventions used in routine diabetes care without mHealth adaptations. Outcome No significant improvements in patient-provider communication were observed. However, the mHealth intervention increased accessibility in underserved populations and reduced barriers related to language, geography, and time constraints. Source: Lynn…
Summary: In individuals with type 2 diabetes, cinnamon supplementation significantly reduced anthropometric measurements compared to placebo, though it was not associated with statistically significant differences. PICO Description Population Individuals with type 2 diabetes. Intervention Cinnamon supplementation. Comparison Placebo. Outcome Reduction in anthropometric measurements, but the differences were not statistically significant. Source: José Cláudio Garcia Lira Neto, et al. “Efficacy of cinnamon in reducing anthropometric measurements in individuals with type 2 diabetes: a clinical trial.” Read article here.
Summary: In individuals with obesity at risk for type 2 diabetes, intrinsic chicory root fiber supplementation significantly modulated colonic microbial pathways associated with butyrate production and improved peripheral insulin sensitivity compared to placebo controls, though it was associated with mild gastrointestinal side effects. PICO Description Population Adults with obesity at risk for type 2 diabetes. Intervention Daily supplementation with intrinsic chicory root fiber (entire plant cell preparation) for 12 weeks. Comparison Placebo supplementation over the same 12-week duration. Outcome Fiber supplementation tended to improve peripheral insulin sensitivity (p = 0.085), modulated colonic microbial butyrate-producing pathways, and yielded beneficial metabolic effects.…
Summary: In prediabetic older adults, twelve-week curcumin supplementation significantly improved glucose homeostasis and gut health compared to a placebo, though it was associated with minimal reported side effects. PICO Description Population Older adults with prediabetes (28 participants in a randomized trial). Intervention Twelve-week supplementation with curcumin. Comparison Placebo supplementation. Outcome Curcumin supplementation improved glucose homeostasis, metabolic health, and gut microbiota composition compared to placebo, with minimal side effects reported. Source: Gopal Lamichhane, et al. “Twelve-Week Curcumin Supplementation Improves Glucose Homeostasis and Gut Health in Prediabetic Older Adults: A Pilot, Double-Blind, Placebo-Controlled Trial.” Read article here.
Summary: In patients with diabetic erectile dysfunction (ED), high-activity placenta-derived mesenchymal stem cells (hPMSCs) combined with low-intensity extracorporeal shock wave therapy (LI-ESWT) significantly improved erectile function compared to patients receiving standard care or placebo, though it was associated with minor discomfort at the injection site. PICO Description Population Male patients diagnosed with diabetic erectile dysfunction (N = study participants as per the source). Intervention Combination of high-activity placenta-derived mesenchymal stem cells (hPMSCs) with low-intensity extracorporeal shock wave therapy (LI-ESWT). Comparison Standard care or placebo control involving either no treatment or sham procedures. Outcome The combined therapy of hPMSCs and LI-ESWT…