The EDIC study demonstrated that 6.5 years of intensive glycaemic therapy during the DCCT reduced cardiovascular events by 42–57% over 17 years of follow-up despite subsequent HbA1c convergence between groups, establishing the concept of metabolic memory and providing foundational evidence that early intensive glycaemic control produces durable cardiovascular protection extending decades beyond the intervention period.
Author: Hormone Insight Editorial Team
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The Diabetes Control and Complications Trial demonstrated that intensive insulin therapy targeting near-normal blood glucose reduced the risk of developing retinopathy by 76% in primary prevention and slowed progression by 54% in secondary intervention, while also substantially reducing nephropathy and neuropathy, establishing the foundational evidence for tight glycaemic control in type 1 diabetes.
A man convinced his wife’s hormones are the problem. A woman whose husband answers every question for her. Two composite vignettes from one fictional clinic afternoon.
A bride who needs answers before Saturday. A sixteen-year-old boy with mild numbers and a mother carrying more hope than he is. Two composite vignettes from one fictional clinic morning.
A double-blind RCT finds vitamin D improves insulin secretion and HOMA-IR but not fasting glucose in women with prediabetes. PICO summary and clinical expert commentary.
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Summary: In pregnant women diagnosed with gestational diabetes mellitus (GDM), continuous glucose monitoring (CGM) significantly improved glycemic control compared to self-monitoring of blood glucose (SMBG), though it was associated with higher cost and occasional device-related skin irritation. PICO Description Population Pregnant individuals diagnosed with gestational diabetes mellitus (GDM). Intervention Continuous glucose monitoring (CGM) for blood glucose management during pregnancy. Comparison Traditional self-monitoring of blood glucose (SMBG) methods using finger-stick glucose testing. Outcome CGM was associated with better glycemic control, including reduced hyperglycemic episodes and improved time-in-range measures. However, it incurred higher costs and some participants experienced mild skin irritation from…
A pilot RCT finds prebiotic inulin enriches SCFA-producing gut bacteria but does not improve HbA1c in Indian children with type 1 diabetes. PICO summary and expert commentary.