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    PICO Type 2 Diabetes Reviewed clinical summary Evidence Card

    Reviewed clinical summary · Source-linked · Educational use only

    Should Diabetic Patients Take Antibiotics After a Simple Tooth Extraction?

    Clinical Bottom Line

    Summary: In type 2 diabetic patients undergoing single simple dental extractions, amoxicillin did not significantly reduce the risk of alveolar osteitis, infection, or delayed healing compared to placebo, and its use is considered unnecessary when managing these cases. PICO Description Population Patients…

    Summary: In type 2 diabetic patients undergoing single simple dental extractions, amoxicillin did not significantly reduce the risk of alveolar osteitis, infection, or delayed healing compared to placebo, and its use is considered unnecessary when managing these cases.
    PICO Description
    Population Patients with type 2 diabetes undergoing single simple dental extractions.
    Intervention Administration of 500 mg amoxicillin.
    Comparison Placebo treatment.
    Outcome No significant differences were observed for alveolar osteitis, infections, or healing delays between groups. The study suggests that antibiotic use in these cases may not be necessary.
    RCT Acta Odontol Latinoam · 2025

    Amoxicillin vs placebo for diabetic tooth extractions

    RCT · type 2 diabetes · 14 days

    Trial design
    T2DM, simple extraction Enrolled & assessed RANDOMISED 1:1 Amoxicillin 500 mg pre-op n = 28 Placebo Pre-op n = 28 Alveolar osteitis / infection rate
    Proportion reaching endpoint
    Not estimable % 0% Amoxicillin 0% Placebo ARR0% (no events)
    Alveolar osteitis
    0% vs 0%
    No cases either arm
    Infection
    0% vs 0%
    Local or systemic
    Delayed healing
    NS
    No difference at 7 d
    Analgesics used
    More on amoxicillin
    p<0.05
    ⬡ Bottom Line

    No alveolar osteitis or infection occurred in either arm after simple extractions in controlled type 2 diabetics. Amoxicillin gave no benefit and was linked to more analgesic use, so routine prophylaxis appears unnecessary.

    Source: Matias Garcia-Blanco, et al. “Randomized controlled trial comparing antibiotics to placebo for single simple dental extractions in diabetic patients.” Read article here.

    Educational use: Hormone Insight is intended for healthcare professionals and learners. Interpret each summary alongside the primary source, local guidance, and patient-specific clinical judgement.

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