Summary: In patients with diabetic macular edema (DME),intravitreal aflibercept combined with dexamethasone phosphate significantly improved short-term structural and functional outcomes…
Browsing: PICO
A SURMOUNT-1 analysis finds tirzepatide improves insulin sensitivity (mostly via weight loss) and beta-cell function (mostly drug-driven) in obesity without diabetes. PICO summary and commentary.
A post-hoc analysis of 307 ACCORD-BP participants with type 2 diabetes and prior stroke links intensive systolic blood pressure control to fewer cardiovascular events. PICO summary and expert commentary.
Summary: In diabetic patients in Egypt, the Diabetes Conversation Map (TM) program significantly improved knowledge retention, self-management behaviors, and self-efficacy…
A SURMOUNT-1 analysis finds 90% of early non-responders to tirzepatide still reached 5% weight loss by week 72, supporting extending treatment. PICO summary and commentary.
A 24-week trial finds high-phenolic olive oil reduces insulin resistance in type 2 diabetes, but without changing lipids or blood pressure. PICO summary and commentary.
A crossover trial finds the Omnipod 5 Activity feature reduces insulin and blunts exercise glucose drops in type 1 diabetes, though hypoglycemia rates were unchanged. PICO summary and commentary.
A double-blind RCT finds nanocurcumin does not improve pain or neuropathy outcomes in diabetic peripheral neuropathy. PICO summary and expert commentary.
Summary: In patients with diabetic peripheral neuropathy (DPN), once-daily prolonged-release (PR) pregabalin significantly improved pain management compared to placebo and…
A randomized open-label pilot trial tested whether slower, flexible semaglutide titration reduces gastrointestinal dropout in type 2 diabetes versus the label regimen. PICO summary and expert commentary.