Evidence summaries for semaglutide across type 2 diabetes, obesity, cardiovascular outcomes, kidney outcomes, safety, dosing, and comparative therapy.
In patients with type 2 diabetes, once-weekly semaglutide significantly improved glycaemic control (HbA1c reduction) and reduced body weight in a dose-dependent manner compared to placebo, with efficacy at the highest doses surpassing that of daily liraglutide, though it was associated with gastrointestinal side effects.
In patients with type 2 diabetes on diet and exercise or metformin, oral semaglutide significantly improved glycemic control (HbA1c reduction) and weight loss in a dose-dependent manner compared to placebo, with similar efficacy to subcutaneous semaglutide, though it was associated with higher rates of gastrointestinal side effects.
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