A post-hoc pooled analysis of four semaglutide trials found a lower risk of cardiovascular death or worsening heart failure in patients with HFpEF, though cardiovascular death alone was not reduced. PICO summary and expert commentary.
Browsing: GLP-1 Receptor Agonists
Clinical trial summaries for GLP-1 receptor agonists, including cardiovascular outcomes, glycaemic control, obesity, kidney outcomes, tolerability, and practice implications.
A prespecified secondary analysis of the pooled STEP-HFpEF and STEP-HFpEF DM trials examining whether semaglutide 2.4 mg benefits in obesity-related HFpEF differ by sex. PICO summary and expert commentary.
A prespecified analysis of the SELECT trial examining whether semaglutide 2.4 mg reduces cardiovascular and heart failure outcomes in patients with obesity and prevalent heart failure. PICO summary and expert commentary.
A small single-centre study found that adding a long-acting GLP-1 receptor agonist to metformin lowered BMI but did not show a significant between-group glycaemic advantage. PICO summary and expert commentary.
A prespecified SELECT analysis shows semaglutide reduced cardiovascular events in overweight or obese adults without diabetes regardless of baseline HbA1c or HbA1c change. PICO summary and expert commentary.
A prespecified FLOW analysis found once-weekly semaglutide 1 mg lowered the composite of heart failure events or cardiovascular death by 27 percent in type 2 diabetes with chronic kidney disease. PICO summary and expert commentary.
An echocardiography substudy of the STEP-HFpEF Program found that once-weekly semaglutide 2.4 mg attenuated left atrial and right ventricular remodelling versus placebo, without changing left ventricular systolic function. PICO summary and expert commentary.
A small double-blind randomized trial found once-daily oral semaglutide 50 mg lowered ad libitum energy intake and body weight versus placebo over 20 weeks, with no delayed gastric emptying. PICO summary and expert commentary.
PIONEER 11, a 26-week Phase IIIa trial, found oral semaglutide monotherapy lowered HbA1c across all doses and reduced body weight at 7 mg and 14 mg versus placebo in a predominantly Chinese type 2 diabetes population. PICO summary and expert commentary.
A 12-week pilot randomised trial in 30 adults with type 2 diabetes compared a very-low calorie diet, semaglutide, and their combination on weight, body composition, and beta-cell function. PICO summary and expert commentary.