A double-blind RCT finds empagliflozin gives broader cardiometabolic benefit than sitagliptin or metformin as add-on therapy in type 2 diabetes. PICO summary and commentary.
Browsing: PICO
Structured PICO summaries for doctors and healthcare professionals, covering population, intervention, comparison, outcomes, expert commentary, and references across diabetes, endocrinology, obesity, and cardiometabolic medicine.
An RCT finds a periodontal health programme improves oral hygiene and knowledge in older diabetic patients, but not oral-health quality of life. PICO summary and commentary.
A machine-learning analysis finds lower baseline periodontal severity and HbA1c predict better response to gum therapy in diabetes (random forest AUC 0.83). PICO summary and commentary.
A DAPA-MI subanalysis finds dapagliflozin reduces new-onset diabetes after heart attack regardless of glucose or BMI, with most symptom benefit in prediabetes. PICO summary and commentary.
A multicentre RCT finds a CBT-based dietary app improves postprandial glucose and reduces macrosomia in gestational diabetes. PICO summary and commentary.
Summary: In pregnant individuals with gestational diabetes mellitus (GDM), real-time continuous glucose monitoring (CGM) significantly increased the percentage of time…
An RCT finds home dual-task exercise improves executive function and HDL in diabetic postmenopausal women, but does not change the TNF/IL-10 balance or glucose. PICO summary and commentary.
Summary: In patients with clinically significant macular edema (CSME) in type 2 diabetes mellitus, low-dose atorvastatin (10-20 mg) significantly improved…
Summary: In patients with diabetic macular edema (DME),intravitreal aflibercept combined with dexamethasone phosphate significantly improved short-term structural and functional outcomes…
A SURMOUNT-1 analysis finds tirzepatide improves insulin sensitivity (mostly via weight loss) and beta-cell function (mostly drug-driven) in obesity without diabetes. PICO summary and commentary.