Reproductive Endocrinology
PCOS, hypogonadism, fertility, menopause, and hormone therapy.
Letrozole vs Programmed FET in PCOS: No Difference in Pregnancy Rates
A small open-label RCT found no significant difference in clinical pregnancy rates between letrozole ovulation and programmed endometrial preparation for frozen embryo transfer in women with PCOS, with letrozole needing simpler luteal support. PICO summary and expert commentary.
CGM-Guided Individualised Care in Diabetic Pregnancy: A Small RCT
A small single-centre RCT of CGM-guided individualised care versus self-monitoring in 80 women with diabetes in pregnancy, with no between-group glycaemic superiority demonstrated. PICO summary and expert commentary.
Does a Low-Glycemic Carbohydrate Product Improve Maternal Glycemia in Obese Pregnant Women?
A manufacturer-sponsored randomized trial of a low-glycemic-index/slow-digesting carbohydrate product in obese pregnant women found no effect on the primary glycemic outcomes. PICO summary and expert commentary.
Can Moxibustion Plus Low-Dose Tadalafil Improve Erectile Dysfunction in Diabetic Patients?
A three-arm RCT finds moxibustion plus low-dose tadalafil outperforms either alone for diabetic erectile dysfunction, in an unblinded single-centre setting. PICO summary and commentary.
Wuziyuye Decoction Improves Sperm Parameters in Diabetic Asthenospermia: Chinese RCT
An RCT finds Wuziyuye Decoction improves sperm motility and concentration over L-carnitine in diabetic men, but without improving pregnancy rates. PICO summary and commentary.
Can combining semaglutide with metformin improve weight, metabolism, and fertility in women with PCOS?
An RCT finds adding semaglutide to metformin improves weight, testosterone, and natural pregnancy rates in women with PCOS. PICO summary and expert commentary.