Osteoporosis, vitamin D, calcium and parathyroid disorders, and bone-health therapeutics.
A small RCT finds preoperative calcium and magnesium before thyroidectomy yields numerically lower hypocalcaemia and earlier recovery in Graves' patients, but the differences were not significant. PICO summary and commentary.
A 52-week phase III RCT finds sitagliptin preserves hip bone density in women with type 2 diabetes, which declines on placebo, but with no effect at other sites. PICO summary and commentary.
A combined mouse and clinical study finds the anabolic agent rhPTH(1-34) reverses low bone turnover in type 2 diabetic bone disease and improves bone density more than alendronate. PICO summary and commentary.
A double-blind RCT finds a single high dose of vitamin D before an ultramarathon favourably shifts bone turnover markers, though mega-dosing remains experimental. PICO summary and commentary.
A 12-month study finds adolescents with poorly controlled type 1 diabetes have low bone density, but glycaemic change does not correlate with bone, while IGF-1 does. PICO summary and commentary.
A secondary analysis of a weight-loss-maintenance RCT found that low-calorie-diet weight loss raised serum 25(OH)D in both sexes, but further loss and low baseline vitamin D tracked with maintenance only in women. PICO summary and expert commentary.
Three-year REAL4 extension data on once-weekly somapacitan versus daily growth hormone in children with growth hormone deficiency, with PICO summary and expert commentary.
A 12-week randomized controlled trial found light-to-moderate aerobic walking produced no significant between-group change in bone turnover markers versus inactive controls in postmenopausal osteopenia, with functional gains reported. PICO summary and expert commentary.
The phase 3 PaTHway trial finds TransCon PTH frees most adults with hypoparathyroidism from conventional therapy and halves urinary calcium. PICO summary and expert commentary.
Welcome to Hormone Insight. Our mission is to support clinical decision-making with accessible, evidence-based insights from recent studies and trials.
© 2024-2026 Hormone Insight. All rights reserved.
