Adrenal and pituitary disorders: Cushing’s, adrenal insufficiency, acromegaly, prolactinoma, and related conditions.
In CHIRACIC, adrenalectomy improved home-blood-pressure normotension with less medication versus conservative management in unilateral mild autonomous cortisol secretion-associated hypertension.
In ACROINNOVA 1, monthly self-injected CAM2029 maintained IGF-1 control in 72.2% of adults with controlled acromegaly versus 37.5% on placebo withdrawal.
A randomised study finds pure endoscopic pituitary surgery improves goal achievement and pituitary function preservation versus microscopic, with similar long-term outcomes. PICO summary and commentary.
A 50-year follow-up of the Auckland Steroid Trial finds no transgenerational metabolic harm in the grandchildren of antenatal-steroid pregnancies. PICO summary and commentary.
A randomised comparison finds gadobutrol non-inferior to meglumine gadoterate for pituitary DCE-MRI but with a higher Kep to recognise, not a clear superiority. PICO summary and commentary.
Three-year REAL4 extension data on once-weekly somapacitan versus daily growth hormone in children with growth hormone deficiency, with PICO summary and expert commentary.
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