Clinical evidence summaries for type 2 diabetes, including glycaemic therapies, cardiovascular outcomes, kidney protection, complications, technology, obesity, and long-term safety.
A multicentre RCT finds adding orlistat to pioglitazone and metformin improves weight, visceral fat, and insulin sensitivity in obese type 2 diabetes, but not HbA1c. PICO summary and commentary.
A small CGM crossover study finds 30 g/day defatted fenugreek flakes reduces 24-hour glucose excursions and variability in type 2 diabetes. PICO summary and commentary.
A secondary analysis finds probiotics plus omega-3 improve beta-cell function only marginally versus baseline and not versus placebo when adjusted, though secondary metabolic markers improve. PICO summary and commentary.
A single-blind RCT finds pictorial foot-care education substantially improves knowledge and practice scores in people with type 2 diabetes in Karachi slums. PICO summary and commentary.
A combined mouse and clinical study finds the anabolic agent rhPTH(1-34) reverses low bone turnover in type 2 diabetic bone disease and improves bone density more than alendronate. PICO summary and commentary.
A small mechanistic trial in youth-onset type 2 diabetes finds metformin and liraglutide shift gut bacteria and bile acids; bile-acid metabolites, not microbiota shifts, track with glucose. PICO summary and commentary.
A four-arm RCT finds only low-dose dexmedetomidine improves perioperative glucose in type 2 diabetes, while higher doses raise it, showing a dose-dependent effect. PICO summary and commentary.
An RCT finds an eHealth app improves HbA1c at 4 months in older diabetes patients, but usage declines by 8 months, raising durability concerns. PICO summary and commentary.
A single-centre RCT reports large glycaemic gains from qigong (Sanxiao Jiuzhi Gong) in type 2 diabetes, but the implausibly large effect size warrants caution. PICO summary and commentary.
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