Diabetes and glycaemic-control evidence summaries covering HbA1c, glucose monitoring, medication comparisons, hypoglycaemia, patient-reported outcomes, and clinical interpretation.
In 28 AID-naive adults with type 1 diabetes, a tubeless open-source hybrid loop (AndroidAPS) raised time in range to 75.6 percent versus 60.4 percent on sensor-augmented pump therapy without added hypoglycaemia. PICO summary and expert commentary.
Two small crossover trials in adults with type 1 diabetes found neither protein source nor carbohydrate glycaemic index significantly altered postprandial glucose. PICO summary and expert commentary.
A manufacturer-sponsored randomized trial of a low-glycemic-index/slow-digesting carbohydrate product in obese pregnant women found no effect on the primary glycemic outcomes. PICO summary and expert commentary.
A Sanofi-sponsored post hoc analysis of the LixiLan-L-CN trial reports that iGlarLixi lowered residual hyperglycaemia more than insulin glargine alone in Chinese adults with type 2 diabetes. PICO summary and expert commentary.
A Phase 2 randomised trial in 145 adults found once-weekly ecnoglutide lowered HbA1c by up to 2.39% versus 0.55% with placebo over 20 weeks. PICO summary and expert commentary.
A post hoc analysis of SUSTAIN China asked whether baseline traits modify the glycaemic effect of once-weekly semaglutide versus sitagliptin in type 2 diabetes. PICO summary and expert commentary.
A J-DOIT2 secondary analysis finds prior dropout history strongly predicts future dropout from diabetes care, with very high HbA1c a further risk marker. PICO summary and commentary.
A small randomized three-arm trial comparing empagliflozin, sitagliptin, and metformin on glycemic and cardio-metabolic parameters in type 2 diabetes, with significance shown mainly against the metformin arm. PICO summary and expert commentary.
A multicentre randomised controlled trial tested whether a cognitive behavioural therapy-based digital dietary programme improved glycaemic control and pregnancy outcomes in gestational diabetes. PICO summary and expert commentary.
An RCT finds the Diabetes Conversation Map improves knowledge, self-management, and self-efficacy in type 2 diabetes, though without clinical endpoints. PICO summary and commentary.
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