An RCT finds triple therapy with a statin, SGLT2 inhibitor, and PCSK9 inhibitor lowers lipids more than monotherapy in ischemic heart disease. PICO summary and commentary.
Browsing: Lipids & Statins
Summary: In patients undergoing laparoscopic sleeve gastrectomy (LSG), a combination of preoperative HDL-C and visceral adipose tissue (VAT) significantly predicted…
Summary: In patients with clinically significant macular edema (CSME) in type 2 diabetes mellitus, low-dose atorvastatin (10-20 mg) significantly improved…
A 52-week trial finds semaglutide shifts lipoprotein subfractions toward a less atherogenic profile in type 2 diabetes, independent of weight or glucose change. PICO summary and commentary.
A randomised crossover trial found 60 g/day of mixed nuts for 16 weeks lowered apolipoprotein B and VLDL and LDL particle numbers in older adults with overweight or obesity. PICO summary and expert commentary.
A post-hoc pooled analysis of three phase 3 trials testing tafolecimab 450 mg every four weeks for LDL-C lowering in Chinese adults with type 2 diabetes and hypercholesterolemia. PICO summary and expert commentary.
A FOURIER subgroup analysis of 197 participants asks whether evolocumab cuts cardiovascular events in type 1 diabetes with established ASCVD. PICO summary and expert commentary.
A double-blind RCT testing whether the Omentin-1 Val109Asp genotype modifies vitamin D’s effects on HDL-C, insulin resistance and abdominal obesity in prediabetic women. PICO summary and expert commentary.
A prediction-model study finds a nomogram of preoperative HDL-C and visceral fat forecasts visceral fat loss after sleeve gastrectomy (AUC 0.88). PICO summary and commentary.
Clinical Context Bariatric surgery produces dramatic weight loss and metabolic improvement, but outcomes vary substantially between patients. Understanding what predicts…