Does an Extra Levothyroxine Dose During Ramadan Help Keep TSH in Range?
A 103-patient randomized trial tested an extra 25 mcg of levothyroxine during Ramadan against standard weight-based dosing in hypothyroidism. PICO summary and expert commentary.
Hormone Insight Editorial Team
Clinical archive
Aerobic Walking in Postmenopausal Osteopenia: No Between-Group Change in Bone Turnover Markers
A 12-week randomized controlled trial found light-to-moderate aerobic walking produced no significant between-group change in bone turnover markers versus inactive controls in postmenopausal osteopenia, with functional gains reported. PICO summary and expert commentary.
HIIT and Insulin Sensitivity in Prediabetes: A 4-Arm RCT
A 4-arm randomised trial in older adults with prediabetes found HIIT improved peripheral but not whole-body insulin sensitivity, with walking showing the opposite pattern. PICO summary and expert commentary.
Can Social Networks Help Reduce Obesity? A Trial Protocol (ROBUST)
The ROBUST study protocol describes a planned randomized trial of a social network-enhanced lifestyle intervention for obesity in Black and Hispanic adults, with no outcome results yet. PICO summary and expert commentary.
Autologous Platelet Gel vs Standard Dressings for Diabetic Foot Ulcers: A Randomised Controlled Trial
A 96-patient randomised controlled trial of manufacturer-developed autologous platelet gel versus standard dressings for chronic neuropathic diabetic foot ulcers, with PICO summary and expert commentary.
PREDIABETEXT: Designing and Recruiting for a Digital Diabetes-Prevention Trial
A design, recruitment, and baseline-characteristics report for the PREDIABETEXT cluster randomised trial of a digital diabetes-prevention intervention, with no efficacy outcomes yet reported. PICO summary and expert commentary.
Is a Nurse-Led Telephone Program Cost-Effective in Type 2 Diabetes With Depression?
A secondary cost-consequence and budget impact analysis of the TELE-DD trial found a nurse-led telephone program for nonadherent Type 2 diabetics with comorbid depression became cheaper per glycaemically controlled patient by 12-18 months. PICO summary and expert commentary.
Dnurse App for T2DM Self-Management: No Significant HbA1c Benefit in a Factorial RCT
A 2-centre factorial RCT in 273 Chinese adults with type 2 diabetes found the Dnurse app did not significantly improve HbA1c attainment, though systolic blood pressure fell in the app arms. PICO summary and expert commentary.
Structured Diet and Exercise Delayed, But Did Not Prevent, Diabetes in Prediabetes
A 6-month structured anti-inflammatory diet-and-exercise programme in 542 adults with prediabetes delayed diabetes onset but did not lower 8-year incidence. PICO summary and expert commentary.
Is the MiniMed 780G Cost-Effective for Type 1 Diabetes?
A manufacturer-funded cost-effectiveness model found the MiniMed 780G closed-loop system cost-effective versus injections with isCGM in US type 1 diabetes at $100,000 per QALY (ICER $68,402 over 4 years, $38,842 lifetime). PICO summary and expert commentary.