A 13-week randomised trial found automated insulin delivery sharply lowered HbA1c in youth with type 1 diabetes but objectively reduced sleep efficiency and increased night-time wakefulness. PICO summary and expert commentary.
A 6-month randomised trial in older adults with type 2 diabetes found home telemedicine plus Health Belief Model education cut HbA1c by 0.42% more than usual care. PICO summary and expert commentary.
In 28 AID-naive adults with type 1 diabetes, a tubeless open-source hybrid loop (AndroidAPS) raised time in range to 75.6 percent versus 60.4 percent on sensor-augmented pump therapy without added hypoglycaemia. PICO summary and expert commentary.
A randomized crossover trial found the cardiac output response to 3-hydroxybutyrate was blunted by roughly 80% in type 1 diabetes, with no gain in systolic function and reduced ventricular work efficiency. PICO summary and expert commentary.
An oral GLP-1 receptor agonist lowered HbA1c and body weight in phase 2 but was halted early after transaminase elevations ended its development. PICO summary and expert commentary.
Two small crossover trials in adults with type 1 diabetes found neither protein source nor carbohydrate glycaemic index significantly altered postprandial glucose. PICO summary and expert commentary.
A 253-adult randomized trial found that 25% calorie restriction produced consistent enteropancreatic hormone shifts across diet patterns, and that larger shifts were associated with more weight regain afterwards. PICO summary and expert commentary.
A 56-week randomized, double-blind, placebo-controlled trial of liraglutide 3.0 mg for weight recurrence after Roux-en-Y gastric bypass. PICO summary and expert commentary.
A manufacturer-sponsored randomized trial of a low-glycemic-index/slow-digesting carbohydrate product in obese pregnant women found no effect on the primary glycemic outcomes. PICO summary and expert commentary.
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