Hormone Insight Editorial Team
Clinical archive
Can 660-nm low-level laser therapy effectively heal diabetic foot ulcers?
A double-blind dose-response trial finds red and infrared laser all reduce diabetic foot ulcer size over time but with no significant difference between groups; 8-12 J/cm2 gave more responders. PICO summary and commentary.
Can probiotics with omega-3 PUFAs improve pancreatic beta-cell function in type 2 diabetes?
A secondary analysis finds probiotics plus omega-3 improve beta-cell function only marginally versus baseline and not versus placebo when adjusted, though secondary metabolic markers improve. PICO summary and commentary.
“How effective is silicone oil tamponade with dexamethasone for retinal detachment in diabetic retinopathy patients?”
A small RCT finds adding a dexamethasone implant to vitrectomy with silicone oil tamponade reduces recurrent membranes and improves vision in proliferative diabetic retinopathy with detachment. PICO summary and commentary.
“How Effective is Pictorial Education for Foot Care in Type 2 Diabetics in Karachi’s Slums?”
A single-blind RCT finds pictorial foot-care education substantially improves knowledge and practice scores in people with type 2 diabetes in Karachi slums. PICO summary and commentary.
How do rhPTH(1-34) and alendronate treat type 2 diabetic bone disease?
A combined mouse and clinical study finds the anabolic agent rhPTH(1-34) reverses low bone turnover in type 2 diabetic bone disease and improves bone density more than alendronate. PICO summary and commentary.
Does BMI Affect the Benefits of Bivalirudin Over Heparin in Heart Attack Patients?
A prespecified BRIGHT-4 subgroup analysis finds bivalirudin reduces death or major bleeding versus heparin in lower-BMI STEMI patients but not higher-BMI, with a significant interaction. PICO summary and commentary.
How do metformin and liraglutide affect gut microbiome in youth-onset type 2 diabetes?
A small mechanistic trial in youth-onset type 2 diabetes finds metformin and liraglutide shift gut bacteria and bile acids; bile-acid metabolites, not microbiota shifts, track with glucose. PICO summary and commentary.
