An RCT finds combined aerobic and resistance training improves modelled insulin secretion and glucose effectiveness more than either alone in men with type 2 diabetes. PICO summary and commentary.
A 12-month RCT finds daily curcumin reduces liver fat, stiffness, and HbA1c and improves inflammatory and antioxidant markers in obese type 2 diabetes with fatty liver. PICO summary and commentary.
A crossover RCT finds a specific Bifidobacterium animalis probiotic blunts the rise in glucose and insulin resistance and raises immunoglobulins in type 2 diabetes, with modest adjunctive benefit. PICO summary and commentary.
A 2-year pragmatic open-label trial finds once-weekly semaglutide modestly outperforms physician-chosen alternatives on HbA1c targets, with a year-1 weight advantage that fades by year 2. PICO summary and commentary.
A 52-week phase III RCT finds sitagliptin preserves hip bone density in women with type 2 diabetes, which declines on placebo, but with no effect at other sites. PICO summary and commentary.
An RCT finds an interdisciplinary care model with family empowerment improves blood pressure, glucose, and psychosocial outcomes in comorbid hypertension and diabetes. PICO summary and commentary.
An RCT finds adding ezetimibe to metformin raises PPAR-gamma and adiponectin expression and improves insulin resistance in diabetic fatty liver disease, though endpoints are surrogate. PICO summary and commentary.
An early RCT finds weekly Wharton's jelly stem cell-derived exosomes markedly accelerate diabetic foot ulcer healing versus standard care, though the therapy remains investigational. PICO summary and commentary.
A phase-1 crossover study in healthy Korean volunteers found a fixed-dose enavogliflozin/gemigliptin combination pharmacokinetically equivalent to the separate tablets, with food delaying only the time to peak. PICO summary and expert commentary.
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