Summary:
In patients with chronic, non-healing Wagner Grade 1 diabetic foot ulcers (DFUs), borate-based bioactive glass fibre matrix (BBGFM) combined with standard of care (SOC) significantly improved wound healing rates and accelerated ulcer closure compared to standard of care alone over 12 weeks, though it was associated with minor and manageable local adverse events.
| PICO | Description |
|---|---|
| Population | Adults with chronic, non-healing Wagner Grade 1 diabetic foot ulcers. |
| Intervention | Application of borate-based bioactive glass fibre matrix (BBGFM) in combination with standard of care therapy for 12 weeks. |
| Comparison | Standard of care therapy alone over 12 weeks. |
| Outcome | BBGFM plus SOC significantly enhanced wound healing rates and ulcer closure compared to SOC alone. Observed side effects were predominantly minor localized events without serious complications. |
Source: Armstrong, David G., et al. “A Borate-Based Bioactive Glass Advances Wound Healing in Non-Healing Wagner Grade 1 Diabetic Foot Ulcers: A Randomised Controlled Clinical Trial.” Read article here.
