Summary:In type 2 diabetic stage-II periodontitis patients, non-surgical periodontal therapy with adjunctive hyaluronic acid (HA) gel significantly improved periodontal health and HbA1c levels compared to non-surgical periodontal therapy alone, though it was associated with no significant adverse effects.
Source: Reem Al-Abbadi, et al. “Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial.” Read article here.
| PICO | Description |
|---|---|
| Population | Adults with type 2 diabetes and stage-II periodontitis. |
| Intervention | Non-surgical periodontal therapy with adjunctive hyaluronic acid gel. |
| Comparison | Non-surgical periodontal therapy alone (without adjunctive hyaluronic acid gel). |
| Outcome | Patients receiving the adjunctive HA gel had significantly better periodontal health improvement and reduced HbA1c levels compared to those without HA. No significant adverse effects were reported for the adjunctive HA gel therapy. |
RCT
BMC Oral Health · 2025
HA gel adjunct in diabetic periodontitis
RCT · type 2 diabetes · 6 months
Trial design
Change from baseline — both arms
CAL at 6 months
2.62 vs 2.75 mm
No between-group diff (p=0.56)
HbA1c, HA arm
6.58 to 6.45%
Significant within arm (p=0.03)
HbA1c, PMPR arm
6.58 to 6.43%
Not significant (p=0.07)
Adverse events
None
No inadvertent events
⬡ Bottom Line
Both groups improved periodontal measures equally, with no between-group difference in the primary CAL outcome. Adjunctive HA gel produced a small but statistically significant HbA1c reduction (about 0.13%) seen only in the HA arm, of uncertain clinical importance in this 26-patient trial.
P
Population
Controlled type 2 diabetic adults with stage-II grade B periodontitis
I
Intervention
Professional mechanical plaque removal plus topical hyaluronic acid gel
C
Comparator
Professional mechanical plaque removal alone
O
Outcome
Clinical attachment level (primary); HbA1c and other periodontal/radiographic measures (secondary)
