Summary:
In patients with type-II diabetes mellitus (DM) with qi-yin deficiency complicated by asthenospermia, Wuziyuye Decoction significantly improved sperm progressive motility, sperm concentration, and traditional Chinese medicine (TCM) syndrome scores compared to oral L-carnitine solution (control), both in combination with standard glucose-lowering therapy, though it was associated with no severe adverse reactions.
| PICO | Description |
|---|---|
| Population | Male patients diagnosed with type-II diabetes mellitus with qi-yin deficiency syndrome and asthenospermia (n = 100), aged and clinically evaluated at the First Hospital Affiliated to Ningbo University from January 2023 to March 2024. |
| Intervention | Wuziyuye Decoction administered orally for 12 weeks alongside standard Western glucose-lowering medications aimed at controlling fasting blood glucose. |
| Comparison | Oral L-carnitine solution for 12 weeks plus the same standard Western medical glucose control measures. Both groups were evaluated before treatment, after treatment, and during a 24-week follow-up period. |
| Outcome | Wuziyuye Decoction significantly improved sperm progressive motility (PR%) (35.5% vs 29.5%, P<0.05), sperm concentration (54.0 ± 33.4 vs 45.0 ± 34.1 ×10⁶/ml, P<0.05), and TCM syndrome scores (4.5 ± 2.3 vs 17.2 ± 4.5, P<0.05) compared to the control group. No significant differences were observed in semen volume, reproductive hormone levels, or pregnancy outcomes between groups. No serious adverse events reported in either group. |
Source: Yi Yu, et al. “Wuziyuye Decoction for type-II diabetes mellitus with qi-yin deficiency complicated by asthenospermia: A randomized controlled trial.” Read article here.
