STEP UP: Semaglutide 7.2 mg Delivered Additional Weight Loss in Obesity
In STEP UP, semaglutide 7.2 mg reduced body weight by 18.7% versus 3.9% with placebo and outperformed semaglutide 2.4 mg in adults with obesity without diabetes.
Semaglutide
Evidence summaries for semaglutide across type 2 diabetes, obesity, cardiovascular outcomes, kidney outcomes, safety, dosing, and comparative therapy.
REDEFINE 1: CagriSema Produced 20.4% Weight Loss in Adults Without Diabetes
In REDEFINE 1, once-weekly cagrilintide-semaglutide produced 20.4% mean weight loss at 68 weeks versus 3.0% with placebo in adults with overweight or obesity without diabetes.
REDEFINE 2: CagriSema Reduced Weight and HbA1c in Type 2 Diabetes
In REDEFINE 2, CagriSema reduced weight by 13.7% versus 3.4% with placebo at 68 weeks, and 73.5% achieved HbA1c <=6.5% in adults with type 2 diabetes.
Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes (SOUL)
In high-risk type 2 diabetes, once-daily oral semaglutide 14 mg cut major adverse cardiovascular events versus placebo in the SOUL trial, with no kidney benefit shown. PICO summary and expert commentary.
Can Semaglutide Improve Cholesterol Profiles in Type 2 Diabetes?
A 52-week open-label randomized trial found once-weekly semaglutide reduced LDL cholesterol and shifted lipoprotein subfractions toward a less atherogenic profile versus sitagliptin in obese type 2 diabetes. PICO summary and expert commentary.
Is Once-Weekly Semaglutide Effective for Alcohol Use Disorder in Obese Patients?
A Lancet phase 2 RCT finds once-weekly semaglutide 2.4 mg reduces heavy drinking days in alcohol use disorder with obesity. PICO summary and expert commentary for clinicians.
SELECT: Semaglutide 2.4 mg Reduces Cardiovascular Events by 20% in Obese Non-Diabetic Patients with CVD
The SELECT trial demonstrated that semaglutide 2.4 mg reduces 3-point MACE by 20% in overweight or obese adults with pre-existing cardiovascular disease and no diabetes, becoming the first obesity pharmacotherapy trial to demonstrate a hard cardiovascular endpoint benefit and establishing GLP-1 receptor agonism as a cardiovascular intervention in non-diabetic obesity.
STEP 1: Semaglutide 2.4 mg Produces Unprecedented 14.9% Weight Loss in Obesity Without Diabetes
STEP 1 demonstrated that once-weekly semaglutide 2.4 mg produced a mean weight reduction of 14.9% compared with 2.4% with placebo in adults with obesity without type 2 diabetes, with a third of participants losing more than 20% of body weight, setting a new benchmark for pharmacological weight management and preceding the cardiovascular outcomes evidence from SELECT.
SUSTAIN-6: Semaglutide Reduces MACE and Stroke in High-Risk Type 2 Diabetes
The SUSTAIN-6 trial demonstrated that once-weekly semaglutide reduced 3-point MACE by 26% in high-cardiovascular-risk type 2 diabetes, driven primarily by a significant 39% reduction in nonfatal stroke, while identifying a retinopathy complication signal attributable to rapid glucose lowering in patients with pre-existing retinopathy.
Does Semaglutide’s Cardiovascular Benefit Depend on Weight Loss in the SELECT Trial?
A prespecified SELECT analysis finds semaglutide's cardiovascular benefit is largely independent of weight loss, with only a third mediated by waist reduction. PICO summary and commentary.