In STEP UP, semaglutide 7.2 mg reduced body weight by 18.7% versus 3.9% with placebo and outperformed semaglutide 2.4 mg in adults with obesity without diabetes.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
In overweight or obese adults with early type 2 diabetes, dapagliflozin added to calorie restriction increased 12-month remission from 28% to 44%.
In REDEFINE 1, once-weekly cagrilintide-semaglutide produced 20.4% mean weight loss at 68 weeks versus 3.0% with placebo in adults with overweight or obesity without diabetes.
In REDEFINE 2, CagriSema reduced weight by 13.7% versus 3.4% with placebo at 68 weeks, and 73.5% achieved HbA1c <=6.5% in adults with type 2 diabetes.
A single-centre Egyptian RCT found the Diabetes Conversation Map programme improved diabetes knowledge, self-management, and self-efficacy questionnaire scores versus standard education (p < 0.001), with no clinical endpoints reported. PICO summary and expert commentary.
A randomised controlled trial of a psychosocial weight-management programme in overweight or obese pregnant women improved diet and activity but not gestational diabetes, preeclampsia, or caesarean rates. PICO summary and expert commentary.
A multicentre randomised trial testing a CBT-based WeChat dietary programme against standard care for postprandial glucose and pregnancy outcomes in gestational diabetes. PICO summary and expert commentary.
A Brazilian randomized community trial reports preliminary reach and adherence for group-based nutrition interventions in primary care obesity management. PICO summary and expert commentary.
A secondary analysis of a 12-month randomized trial found 4:3 intermittent fasting improved binge and uncontrolled eating versus daily calorie restriction, with no difference in appetite hormones. PICO summary and expert commentary.
A 6-month randomized sub-analysis found that a multicomponent weight-loss program shifted gut microbiota and linked Faecalibacterium abundance to fat-mass loss, though causation was not established. PICO summary and expert commentary.