Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A multicentre randomised trial testing a CBT-based WeChat dietary programme against standard care for postprandial glucose and pregnancy outcomes in gestational diabetes. PICO summary and expert commentary.
A Brazilian randomized community trial reports preliminary reach and adherence for group-based nutrition interventions in primary care obesity management. PICO summary and expert commentary.
A secondary analysis of a 12-month randomized trial found 4:3 intermittent fasting improved binge and uncontrolled eating versus daily calorie restriction, with no difference in appetite hormones. PICO summary and expert commentary.
A 6-month randomized sub-analysis found that a multicomponent weight-loss program shifted gut microbiota and linked Faecalibacterium abundance to fat-mass loss, though causation was not established. PICO summary and expert commentary.
A small non-randomised secondary analysis comparing home- and gym-based exercise in older adults with obesity during COVID-19 lockdowns, with PICO summary and expert commentary.
A 30-participant pilot randomised trial of an 8-week intensive exercise protocol versus diet plus brisk walking in young adults with obesity, with PICO summary and expert commentary.
A post-hoc analysis of the SPRINT trial finds a higher triglyceride-glucose index is associated with greater cardiovascular risk in controlled hypertension, significant only under standard blood pressure treatment. PICO summary and expert commentary.
A small single-blind RCT found that a family-centered empowerment program raised illness acceptance and self-management scores at six weeks in adults with type 2 diabetes. PICO summary and expert commentary.
A one-year randomised controlled trial testing whether pharmacist-led collaborative care improves EQ-5D quality of life and HbA1c versus routine care in adults with diabetes. PICO summary and expert commentary.
A secondary analysis of a 6-month randomized trial found that higher baseline weight-loss self-efficacy predicted at least 5% weight loss in both diet arms, with BMI and age as arm-specific predictors. PICO summary and expert commentary.
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