Summary:
In patients with type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), daily dietary fiber supplementation for 12 weeks significantly improved glycemic control and reduced hepatic fibrosis markers compared to standard diabetes education alone and a lower fiber dose (12g/day), though it was associated with no significant change in BMI, possibly due to increased caloric intake from fiber supplements.
| PICO | Description |
|---|---|
| Population | Adults diagnosed with type 2 diabetes mellitus (T2DM) combined with metabolic dysfunction-associated steatotic liver disease (MASLD), recruited between January and March 2024. |
| Intervention | Daily dietary fiber supplementation (24 grams per day via two packets, each containing 12g dietary fiber), administered for 12 weeks alongside standard health education. |
| Comparison | Control group receiving standard diabetes education only, and a second intervention group receiving 12 grams of dietary fiber daily (one packet). |
| Outcome | The 24g/day dietary fiber group showed significant reductions in HbA1c (-1.6 ± 0.6 vs -0.6 ± 0.5; P<.001) and fasting plasma glucose (FPG) at weeks 8 and 12 compared to both the 12g/day group and the control group. Significant improvements in FIB-4 scores were also observed, indicating reduced liver fibrosis. No significant change in BMI was noted for the high-fiber group. |
Source: Xi-Shuang Chen, et al. “Impact of a high dietary fiber cereal meal intervention on the progression of liver fibrosis in T2DM with MASLD.” Read article here.
