Summary:
In overweight and obese adults, standardized extracts of Dichrostachys glomerata and Cissus quadrangularis significantly increased GLP-1 secretion, reduced DPP-4 activity, and improved metabolic parameters compared to placebo and were comparable in effect to daily semaglutide (3–14 mg), though it was associated with no notable adverse effects reported.
| PICO | Description |
|---|---|
| Population | 248 overweight or obese adults (BMI 25–34.9 kg/m²; mean age 41.3 ± 0.3 years) participating in a 16-week randomized, double-blind, placebo-controlled trial. |
| Intervention | Daily oral administration of 400 mg Dichrostachys glomerata extract (DGE) or 300 mg Cissus quadrangularis extract (CQE). |
| Comparison | Placebo group and semaglutide group (dose-escalated from 3 mg to 14 mg daily). |
| Outcome | Both DGE and CQE groups showed significant increases in GLP-1 levels (+38.6 pg/mL and +42.2 pg/mL), reductions in DPP-4 activity (-15.3% and -17.8%), decreases in body weight (-5.2% and -5.8%) and fat mass (-10.3% and -10.9%), improved satiety (+25.6% and +27.4%), and reduced energy intake (-16.2% and -17.5%) compared to placebo. Results were comparable to those seen with semaglutide. No major adverse effects reported. |
Source: Janvier Youovop, et al. “Effects of Dichrostachys glomerata and Cissus quadrangularis Extracts on GLP-1 Secretion and DPP-4 Activity in Overweight and Obese Individuals: A Randomized Controlled Trial.” Read article here.
