Summary:
In overweight and obese adults undergoing caloric restriction, twice-daily supplementation with exogenous β-hydroxybutyrate (BHB) mineral salts significantly reduced fat mass and improved body composition through lean mass preservation compared to placebo (maltodextrin), both groups under the same hypocaloric diet, though it was associated with no adverse metabolic side effects.
| PICO | Description |
|---|---|
| Population | Overweight and obese adults participating in an 8-week caloric restriction regimen. |
| Intervention | Twice-daily oral administration of racemic β-hydroxybutyrate (BHB) mineral salts alongside a modest hypocaloric diet. |
| Comparison | Placebo group receiving twice-daily maltodextrin alongside the same hypocaloric diet. |
| Outcome | Within-group analysis of the BHB group showed significant fat mass reduction (-2 kg), increased lean-to-fat mass ratio, and improved body fat percentage without reductions in lean mass or resting metabolic rate. LDL cholesterol decreased, and other metabolic biomarkers remained stable. No significant group × time interactions were detected. |
Source: Eliza J Roeth, et al. “Effect of Exogenous Ketones as an Adjunct to Low-Calorie Diet on Metabolic Markers.” Read article here.
