Summary:
In women with type 2 diabetes mellitus, combined aerobic and resistance training along with astaxanthin supplementation significantly improved oxidative stress and inflammatory markers, metabolic indices, and modulated redox-sensitive miRNAs (miRNA-122, miRNA-126-3p, miRNA-146a) and Humanin expression compared to control groups without intervention or with either intervention alone, though it was associated with mild gastrointestinal discomfort in some participants.
| PICO | Description |
|---|---|
| Population | Women diagnosed with type 2 diabetes mellitus characterized by oxidative stress and inflammation. |
| Intervention | Combined aerobic and resistance training (CT) plus astaxanthin (AST) supplementation administered concurrently over the study period. |
| Comparison | Control groups receiving no intervention, CT alone, or AST supplementation alone. |
| Outcome | The combined intervention significantly improved oxidative stress markers and inflammatory cytokines, enhanced metabolic parameters, and modulated redox-sensitive microRNAs and Humanin expression compared to controls. Mild gastrointestinal side effects were reported in some participants receiving astaxanthin. |
Source: Aref Basereh, et al. “Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.” Read article here.
