Summary:
In women aged 18–65 years with prediabetes, vitamin D supplementation (50,000 IU biweekly for 12 weeks) significantly improved insulin secretion, HOMA-IR, and 25(OH)D levels compared to placebo, though it was associated with no significant changes in fasting blood sugar, lipid profiles, anthropometric indices, or serum omentin-1 levels.
| PICO | Description |
|---|---|
| Population | Women aged 18–65 years diagnosed with prediabetes. |
| Intervention | Vitamin D supplementation (50,000 IU every two weeks for 12 weeks). |
| Comparison | Placebo group receiving identical schedule. |
| Outcome | Vitamin D significantly increased 25(OH)D levels, improved insulin levels (MD: 0.413 µIU/mL), HOMA-IR (MD: 0.411), and HOMA-β (MD: 29.505%). However, there were no significant effects on fasting blood sugar, lipid profile, omentin-1 levels, or anthropometric measures compared to placebo. |
Source: Roghayeh Molani-Gol, et al. “Effects of vitamin D supplementation on metabolic factors, serum omentin-1, and anthropometric indices in middle-aged women with prediabetes: a double-blind randomized controlled trial.” Read article here.
