Summary:
In elderly patients with type 2 diabetes mellitus (T2DM) and sleep disorders, resistance exercise combined with metformin treatment significantly improved glycemic control and sleep quality compared to metformin alone, though it was associated with no major adverse effects.
| PICO | Description |
|---|---|
| Population | Elderly patients (n=180) diagnosed with type 2 diabetes mellitus and experiencing sleep disturbances. |
| Intervention | Combination of metformin plus supervised resistance exercise conducted over a 12-week period. |
| Comparison | Metformin treatment alone (control group), without additional resistance training. |
| Outcome | Patients in the intervention group experienced greater reductions in fasting blood glucose, postprandial glucose, HbA1c, PSQI scores, and insulin resistance (HOMA-IR). Improved sleep architecture and increased melatonin levels were also observed compared to the control group. No significant adverse effects were reported. |
Source: Xiang Li, et al. “Effects of resistance exercise combined with metformin on glycemic stability and sleep quality in elderly patients with type 2 diabetes mellitus with sleep disorders.” Pak J Pharm Sci. 2025 Nov-Dec;38(6):2087-2097. Read article here.
