| PICO | Description |
|---|---|
| Population | Patients with diabetic foot ulcers experiencing impaired wound healing and glycemic dysregulation. |
| Intervention | Topical application of ozonated olive oil as an adjunctive therapy to standard wound care. |
| Comparison | Standard wound care without the addition of topical ozonated olive oil. |
| Outcome | Significant enhancement in wound healing rates, improvement in quality of life scores, better glycemic control, and reduced inflammatory markers were observed in the intervention group compared to controls. Side effects were minimal and well-tolerated. |
RCT
Lipids Health Dis · 2025
Ozonated olive oil for diabetic foot ulcers
RCT · type 2 diabetes · 4 weeks
Trial design
Change from baseline — both arms
BWAT score
22.3 vs 26.1
p<0.001
Quality of life
50.1 vs 57.8
p<0.001
HbA1c
7.1% vs 7.7%
p=0.005
hs-CRP
2.9 vs 3.6 mg/L
p=0.006
⬡ Bottom Line
Adjunctive topical ozonated olive oil improved wound healing, quality of life, glycaemic control and inflammation versus standard care alone over 4 weeks. Lipid profile and IL-6/TNF-alpha were unchanged.
P
Population
Adults with type 2 diabetes and Wagner grade 1-2 diabetic foot ulcers
I
Intervention
Daily topical ozonated olive oil plus standard wound care
C
Comparator
Standard wound care alone
O
Outcome
Wound severity (BWAT), quality of life, glycaemic control, inflammation