Summary:
In well-controlled diabetic and non-diabetic patients undergoing surgery, a single intraoperative dose of dexamethasone did not significantly increase blood glucose levels (did not reach hyperglycemic values >180 mg/dL) compared to placebo, though it was associated with a transient hyperglycemic response without clinical significance and was effective as prophylaxis for postoperative nausea and vomiting (PONV).
| PICO | Description |
|---|---|
| Population | Well-controlled diabetic and non-diabetic adult patients undergoing surgery. |
| Intervention | Single intraoperative dose of dexamethasone. |
| Comparison | Placebo administration during surgery. |
| Outcome | Dexamethasone did not cause a clinically significant increase in blood glucose (levels remained below 180 mg/dL), demonstrated effective prophylaxis against postoperative nausea and vomiting, though it induced a transient hyperglycemic response. |
Source: Nadia Rose, et al. “The Effect of Single Intraoperative Dose of Dexamethasone on the Blood Glucose Concentration in Diabetic and Non-Diabetic Patients: A Double Blinded Randomized Control Study.” Read article here.
