Summary:
In patients with chronic high-altitude disease (CHAD), hydrogen-rich water (HRW) supplementation for 60 days significantly downregulated inflammation- and cytokine-related gene pathways compared to placebo water (PW), though it was associated with a non-significant downward trend in oxidative stress and inflammation markers, and no major side effects reported.
| PICO | Description |
|---|---|
| Population | Adults diagnosed with chronic high-altitude disease (CHAD); n = 50 enrolled, 43 completed (HRW group, n = 23; PW group, n = 20). |
| Intervention | Daily intake of hydrogen-rich water (HRW) over a 60-day period. |
| Comparison | Daily intake of placebo water (PW) over the same 60-day period. |
| Outcome | HRW supplementation led to significant transcriptional downregulation of cytokine and inflammation-related pathways, and identified six hub genes linked to inflammatory responses. Clinical measurements showed a non-significant trend toward reduced oxidative stress and inflammation, suggesting HRW’s potential as a protective adjuvant therapy in CHAD. |
Source: Zhang, Qian, et al. “Hydrogen-rich water supplementation attenuates oxidative stress and inflammation in chronic high-altitude disease patients: A double-blind randomized placebo-controlled study.” Read article here.
