Structured Summary:
In patients with type 2 diabetes mellitus (T2DM), the triglyceride-glucose-weight-adjusted waist index (TyG-WWI) was significantly associated with increased cardiovascular outcomes and total mortality (TM) compared to patients with lower TyG-WWI levels, though it was associated with limited predictive value in certain subgroups.
| PICO | Description |
|---|---|
| Population | Patients with type 2 diabetes mellitus (T2DM), based on data from 10,092 participants enrolled in the ACCORD/ACCORDION trials. |
| Intervention | Measurement of triglyceride-glucose-weight-adjusted waist index (TyG-WWI), which combines triglycerides, glucose, weight, and waist circumference to assess metabolic health. |
| Comparison | Patients with lower TyG-WWI levels or less pronounced metabolic derangements. |
| Outcome | Higher TyG-WWI was significantly associated with increased risk of cardiovascular outcomes and total mortality (TM). Subgroup and sensitivity analyses confirmed the robustness of the findings, though the predictive ability varied across different patient characteristics. |
Source: Maojun Liu, et al. “Association and predictive value of the triglyceride-glucose-weight adjusted waist index for cardiovascular outcomes in patients with type 2 diabetes.” BMC Medicine. Read article here.
