Summary: In patients with diabetes mellitus-induced erectile dysfunction (DMED), moxibustion combined with low-dose tadalafil significantly improved erectile function by increasing penile blood flow, benefiting qi, and activating blood circulation compared to low-dose tadalafil alone or moxibustion alone, though it was associated with minimal side effects. PICO Description Population Patients with diabetes mellitus-induced erectile dysfunction (DMED). Intervention Moxibustion combined with low-dose tadalafil. Comparison Tadalafil alone or moxibustion alone. Outcome Combined therapy significantly improved erectile function by increasing penile blood flow and improving clinical symptoms. The treatment was well-tolerated, with minimal side effects reported. Source: Tao Liu, et al. “Moxibustion combined with…
Author: FWA
Summary: In sedentary adults with metabolic syndrome, reducing sedentary time by 1 hour/day significantly improved metabolic flexibility compared to a control group with no change in sedentary behavior, though it was associated with no significant adverse effects. PICO Description Population Sedentary adults with metabolic syndrome, characterized by increased cardiometabolic risks. Intervention Reducing sedentary time by 1 hour per day through increased standing and light physical activity. Comparison A control group with no lifestyle changes and habitual sedentary behavior maintained. Outcome Reduced sedentary time by 1 hour/day led to significant improvements in metabolic flexibility, with better regulation of substrate oxidation and…
Summary: In patients with type 2 diabetes, using the Diabetes for mobile app significantly increased the perception of the disease as more threatening compared to the standard diabetes management approach. Although no specific adverse effects were reported, the increased threat perception could influence long-term psychological outcomes. PICO Description Population Adults diagnosed with type 2 diabetes. Intervention Use of the Diabetes: diabetes self-management mobile app for four weeks. Comparison Standard care for managing type 2 diabetes without the mobile app. Outcome Participants using the app reported a statistically significant increase in perceiving their disease as a greater threat. Long-term psychological impacts…
Summary: In patients with type 2 diabetes, prior dropout history significantly increased the risk of subsequent dropout compared to patients without a dropout history, though higher HbA1c levels (≥10%) presented additional risks for dropout in those with no prior dropout history. PICO Description Population Patients with type 2 diabetes participating in a long-term cohort trial (J-DOIT2-LT008). Intervention Assessment of prior dropout history and HbA1c levels (≥10%) as predictive factors for dropout risk. Comparison Patients without a prior dropout history or with lower HbA1c levels (<10%). Outcome Patients with prior dropout history had a higher risk of subsequent dropout. Additionally, in…
Summary: In obese patients undergoing laparoscopic sleeve gastrectomy (LSG), preoperative high-density lipoprotein cholesterol (HDL-C) and visceral adipose tissue (VAT) measurements significantly predicted VAT reduction compared to other baseline factors not incorporating HDL-C and VAT, though it was associated with limited insights into potential metabolic side effects or generalizability across demographics. PICO Description Population Obese patients undergoing laparoscopic sleeve gastrectomy (LSG). Intervention Preoperative assessment of HDL-C and VAT as combined predictors. Comparison Other baseline factors not including HDL-C and VAT combined predictions. Outcome The combination of HDL-C and VAT significantly predicted VAT reduction following LSG, providing a theoretical basis for improved…
Summary: In patients with pituitary adenomas, endoscopic transsphenoidal surgery significantly improved long-term surgical outcomes, anterior pituitary lobe function, and achievement of initial surgical goals compared to endoscope-assisted microscopic transsphenoidal surgery, though it was associated with similar radiological, endocrinological, rhinological, and ophthalmological results. PICO Description Population Patients with pituitary adenomas undergoing transsphenoidal surgery. Intervention Endoscopic transsphenoidal surgery. Comparison Endoscope-assisted microscopic transsphenoidal surgery. Outcome Endoscopic surgery demonstrated a higher rate of achieving surgical goals and better anterior pituitary lobe function compared to the microscopic technique. Both approaches yielded comparable outcomes for long-term radiological, endocrinological, rhinological, and ophthalmological results. Source: Márton Eördögh, et…
Summary: In patients with mild to moderate anaphylaxis, corticosteroid administration post-eventm did not significantly reduce the recurrence of anaphylaxis compared to no corticosteroid treatment, though it was associated with potential over-treatment and no reduction in recurrence rates. Results suggest against its routine usage in emergency department settings without a clinical rationale. PICO Description Population Patients with mild to moderate anaphylaxis treated in the emergency department (ED). Intervention Administration of corticosteroid post-anaphylaxis episode to prevent recurrence. Comparison No corticosteroid administration post-anaphylaxis treatment. Outcome Corticosteroid use did not significantly reduce recurrence risk of anaphylaxis. Results suggest uncommon recurrence post-ED treatment and a…
Summary: In individuals at high risk for cardiovascular disease, a family-based structured lifestyle modification intervention program significantly improved quality of life and was found cost- effective compared to usual care ,though it was associated with no major adverse effects reported. PICO Description Population Individuals at high risk for cardiovascular disease. Intervention A family-based structured lifestyle modification intervention program targeting cardiovascular risk reduction. Comparison Usual care provided to individuals with high risk of cardiovascular disease. Outcome The intervention significantly improved quality of life and was cost-effective at a threshold of three times gross domestic product per capita. No major adverse effects…
Structured Summary: In patients with type 2 diabetes mellitus (T2DM) and elevated atherosclerotic cardiovascular disease (ASCVD) risk, Curcumin supplementation significantly improved blood pressure, blood glucose control, lipid profiles, and overall cardiovascular health compared to standard care alone, though it was associated with mild gastrointestinal effects. PICO Description Population Adult patients with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD) risk score of ≥ 5%. Intervention Curcumin supplementation (specific dosage not stated). Comparison Standard care without Curcumin supplementation. Outcome Curcumin led to significant reductions in blood pressure, improved blood glucose levels (likely HbA1c), and better lipid profiles. It enhanced…
Summary: In parents of children with acute otitis media, the use of the Ear Pain Decision Aid (EPDA) significantly improved parental knowledge and engagement in shared decision-making compared to standard care without the EPDA, though it was associated with no significant reduction in antibiotic prescribing rates, likely due to the study’s limited sample size. PICO Description Population Parents of children presenting to the emergency department with acute otitis media. Intervention Implementation of the Ear Pain Decision Aid (EPDA) to facilitate shared decision-making during the clinical encounter. Comparison Standard care without the use of a decision aid. Outcome The EPDA significantly…