Summary: In Chinese middle-aged and elderly adults with prediabetes or early diabetes, purified anthocyanins supplementation (160, 320, 640 mg/day) did not significantly improve arterial stiffness or cardiovascular risk factors compared to placebo, and was not associated with notable side effects. PICO Description Population Chinese middle-aged and elderly adults with prediabetes or early-stage diabetes (dysglycemia). Intervention Daily supplementation with purified anthocyanins at doses of 160 mg, 320 mg, and 640 mg over a 12-week period. Comparison Placebo control group receiving no active anthocyanins. Outcome No statistically significant improvements in arterial stiffness (measured by baPWV), ankle-brachial index, four-limb blood pressures, or composite…
Author: FWA
Summary: In adults with diabetes, individualized HbA1c target-setting (5 mmol/mol higher or lower than current HbA1c) did not significantly impact glycaemic outcomes or patient-reported measures compared to alternate target assignment group, though it was associated with high acceptability and improvements in diabetes distress and self-efficacy. PICO Description Population Adults with diabetes participating in a randomised feasibility trial evaluating HbA1c target-setting. Intervention Explicit HbA1c targets set to 5 mmol/mol below participants’ baseline HbA1c levels (Group B). Comparison HbA1c targets set 5 mmol/mol above participants’ baseline HbA1c levels (Group A). Outcome No significant between-group differences were found in HbA1c or psychometric outcomes.…
Summary: In obese women aged 50–80 years with knee osteoarthritis, therapeutic exercise performed in a sitting position significantly reduced pain, improved knee function, and enhanced physical quality of life compared to similar exercises performed in a standing position, though it was associated with less improvement in mental quality of life. PICO Description Population Fifty-four obese women aged 50–80 years diagnosed with knee osteoarthritis. Intervention A 12-week therapeutic exercise program conducted in the sitting position, including aerobics, hip stretching and strengthening, and balance training (45-minute sessions, three times weekly, increasing by 30 minutes every four weeks). Comparison An identical 12-week therapeutic…
Summary: In patients with diabetic nephropathy (DN), treatment with Suyin Detoxification Prescription (SDP) significantly reduced serum creatinine levels and proteinuria compared to standard care or untreated controls, though it was associated with no significant adverse effects reported. PICO Description Population Patients diagnosed with diabetic nephropathy (DN), characterized by progressive renal dysfunction and chronic proteinuria. Intervention Suyin Detoxification Prescription (SDP), a traditional Chinese medicine formula, administered as part of a randomized controlled trial and validated through network pharmacology and molecular assays. Comparison Standard care for DN or untreated diabetic nephropathy model mice; comparisons also included FXR knockout models to validate pathway…
Summary: In adults with type 1 diabetes (T1D), a short-term online educational program significantly reduced diabetes stigma, improved body image, and enhanced body image coping strategies compared to standard care with no intervention, though it was associated with no reported adverse effects. PICO Description Population Adults diagnosed with type 1 diabetes (T1D), recruited using convenience sampling, totaling 88 individuals. Intervention Participation in four online educational sessions focusing on diabetes stigma, body image, and coping strategies. Comparison Control group receiving standard care without any additional educational intervention. Outcome The intervention group had significantly lower posttest DSAS-1 scores (reduced stigma), lower BIS…
Summary: In children and adults with type 1 diabetes (T1D), automated insulin delivery (AID) using MiniMed™ 670G or 770G systems significantly improved HbA1c and reduced time spent in hypoglycemia compared to multiple daily injections (MDI) with or without continuous glucose monitoring, though it was associated with no major increase in severe hypoglycemia or diabetic ketoacidosis rates. PICO Description Population Children and adults aged 2–80 years diagnosed with type 1 diabetes, classified into two subgroups based on baseline HbA1c levels (>8.0% and ≤8.0%), across 32 international centers. Intervention Automated insulin delivery (AID) using MiniMed™ 670G or 770G insulin pump systems over…
Summary: In patients with diabetic nephropathy (DN), a structured nutritional intervention combined with dapagliflozin significantly enhanced glycaemic control, renal function, nutritional status, and quality of life compared to dapagliflozin alone (10 mg/day) or conventional care, though it was associated with no significant difference in adverse event rates. PICO Description Population Adults (n=108) diagnosed with diabetic nephropathy (DN). Intervention Dapagliflozin 10 mg/day combined with a structured Mediterranean diet and oral nutritional supplements. Comparison Dapagliflozin 10 mg/day alone or conventional care without dapagliflozin or nutritional intervention. Outcome The group receiving nutritional intervention plus dapagliflozin showed superior improvements in HbA1c (-1.5% vs -0.9%),…
Summary: In overweight and obese adults (BMI ≥ 23 kg/m2), the combination of high-intensity interval training (HIIT) and asparagus root extract (ARE) supplementation significantly improved oxidative stress markers, inflammation, and lipid metabolism compared to control, HIIT alone, or ARE alone groups (ARE dose: 1.71 ± 0.24 mg/kg/day of 20-hydroxyecdysone), though it was associated with a rise in malondialdehyde levels in the ARE-only group. PICO Description Population Seventy-two overweight or obese adults aged 18–30 years with a BMI ≥ 23 kg/m2. Intervention Combined intervention of high-intensity interval training (modified Tabata, 3x/week for 12 weeks at 80–90% and 40–50% maximal perceived exertion)…
Summary: In patients with type 2 diabetes mellitus (T2DM) suffering from diabetic foot (DF) or diabetic peripheral neuropathy (DPN), alprostadil intravenous injection (40 μg daily for 14–21 days, added to standard care) significantly improved clinical response rates and lipid metabolism compared to standard care alone without alprostadil, though it was associated with a low rate of mild adverse events (3.33%). PICO Description Population Adult patients with type 2 diabetes mellitus diagnosed with either diabetic foot (DF) or diabetic peripheral neuropathy (DPN). Intervention Alprostadil intravenous injection (40 μg/day) administered for 14 to 21 days in addition to standard diabetes care. Comparison…
Summary: In adults with diabetes undergoing telehealth insulin titration, bluetooth-enabled glucometers (BTG) did not demonstrate glycemic superiority but were associated with reduced emergency department visits compared to traditional glucometers (TG), though further studies are needed to assess long-term outcomes and cost-effectiveness. PICO Description Population Adults with diabetes receiving insulin titration via telehealth services. Intervention Use of bluetooth-enabled glucometers (BTG) for remote glucose monitoring during insulin titration. Comparison Use of traditional glucometers (TG) during telehealth insulin titration. Outcome No significant glycemic control difference between BTG and TG; however, BTG use was associated with fewer emergency department visits, indicating potential healthcare utilization…