Summary: In postmenopausal women aged 50–60, combined time-restricted eating (TRE) and Tai Chi exercise significantly improved lipid profiles (total cholesterol and LDL-C) and endothelial function (FMD) compared to TRE alone and conventional lifestyle without intervention, though it was associated with no reported adverse side effects. PICO Description Population Postmenopausal women aged 50–60 years at elevated risk for metabolic and vascular disorders. Intervention Time-restricted eating (8-hour daily feeding window for 8 weeks) combined with three weekly 60-minute sessions of Yang-style 24-form Tai Chi. Comparison Time-restricted eating alone; or no intervention (conventional lifestyle control). Outcome The combination of TRE + Tai Chi…
Author: FWA
Summary: In men with Type 2 diabetes mellitus, combined structured exercise training and broccoli sprout supplementation significantly improved apolipoprotein profiles and metabolic markers compared to exercise or supplementation alone or no intervention, though it was associated with no reported adverse effects. PICO Description Population Forty-four adult males diagnosed with Type 2 diabetes mellitus. Intervention A 12-week combination of structured aerobic and resistance training (3 sessions/week at 60–70% 1RM/VO₂peak) plus 10 g/day of broccoli sprout supplementation taken after meals. Comparison Control group (no intervention); Training only group; Supplementation only group. Outcome The combined group exhibited the greatest improvements: ApoA-I increased (+44.92 ± 6.05 mg/dL),…
Summary: In patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease, long-term dapagliflozin therapy significantly improved coronary flow reserve (CFR) by 34.4% and reduced epicardial adipose tissue (EAT) thickness by 29.18% compared to placebo in the initial 4-week randomized, double-blind phase prior to crossover, though it was associated with no notable adverse effects reported during the follow-up period. PICO Description Population Adults with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD) enrolled in the DAPAHEART trial. Intervention Dapagliflozin 10 mg daily administered for 4 weeks in a randomized phase, followed by long-term treatment up…
Summary: In patients with diabetic foot ulcers, particularly those with peripheral artery disease, intramuscular human placenta-derived cells (PDA-002) significantly increased the rate of complete and sustained wound closure compared to placebo across three dose groups, with the highest efficacy seen at the 3 × 106 cell dose, though it was associated with no treatment-related serious adverse events. PICO Description Population Adults with chronic diabetic foot ulcers, stratified by presence or absence of peripheral artery disease. Intervention Intramuscular injection of human placenta-derived stromal-like cells (PDA-002) administered at doses of 3 × 106, 10 × 106, and 30 × 106 cells. Comparison…
Summary: In patients with diabetic foot ulcers (DFUs), oral sitagliptin (100 mg daily) in combination with standard therapy significantly improved ulcer healing rates, reduced ulcer area, and increased CD34+ endothelial progenitor cells and SDF-1α levels compared to standard conventional therapy alone, though it was associated with no reported adverse effects. PICO Description Population Adults diagnosed with type 2 diabetes mellitus presenting with diabetic foot ulcers (DFUs). Intervention Oral sitagliptin 100 mg once daily added to standard conventional therapy for DFUs. Comparison Standard conventional therapy alone for diabetic foot ulcers. Outcome Sitagliptin significantly improved ulcer healing rates (p < 0.05), reduced…
Summary: In adults with obesity recruited from a weight management center, the Confident Moves (CM) online intervention significantly improved physical activity engagement and self-efficacy compared to usual care including existing center-based supports like meal plans and medications, though it was associated with some procedural variability in secondary feasibility measures. PICO Description Population Adults with obesity enrolled in a local obesity care center in the United States. Intervention Confident Moves (CM) online intervention, a theory-based digital program utilizing behavior change techniques to enhance self-efficacy and promote physical activity. Comparison Usual care provided by the obesity clinic, such as meal planning, behavioral…
Summary: In individuals with type 2 diabetes, a structured five-week aquatic exercise program significantly reduced systolic and diastolic blood pressure, and improved respiratory function and functional capacity over time compared to a control group that received only an educational lecture, though it was associated with no reported side effects. PICO Description Population Adults diagnosed with type 2 diabetes mellitus (DM2), randomized into intervention (n = 27) and control groups (n = 25). Intervention Structured aquatic conditioning program conducted three times per week for five weeks (totaling 15 sessions). Comparison Control group received no physical training but attended the same educational…
Summary: In adults with obesity, periodized combined training with fixed intensity significantly reduced the Visceral Adiposity Index (VAI) compared to combined training with linear intensity increase and a control group, though it was associated with no significant change in metabolic phenotype. PICO Description Population Adults with obesity (BMI ≈33 kg/m²; mean age ≈34 years), including both metabolically healthy and unhealthy phenotypes. Intervention Periodized combined training with fixed intensity over 16 weeks targeting both aerobic and resistance components. Comparison Combined training with linear intensity increase and a non-training control group. Outcome Fixed-intensity training significantly reduced VAI (p < 0.001) in both…
Summary: In patients with type 2 diabetes undergoing laparoscopic colorectal cancer radical resection, intraoperative dexmedetomidine at a loading dose of 1 μg/kg and maintenance dose of 0.25 μg/kg/h significantly maintained better perioperative blood glucose stability compared to control and higher-dose dexmedetomidine groups (0.5 μg/kg/h and 0.75 μg/kg/h), though it was associated with minimal adverse effects and no delay in extubation. PICO Description Population Adult patients with type 2 diabetes mellitus (T2DM) undergoing laparoscopic colorectal cancer radical resection. Intervention Dexmedetomidine, loading dose 1 μg/kg followed by maintenance infusion of 0.25 μg/kg/h (Group D1). Comparison Control group receiving no dexmedetomidine (Group C),…
Summary: In young children aged 2–6 years with overweight or obesity, a parent-based lifestyle support intervention significantly reduced BMI, BMI z-score, and energy/macronutrient intake compared to standard care, though it was associated with no direct side effects reported; response varied by AMY1 gene copy number. PICO Description Population Children aged 2–6 years classified as overweight or obese, participating in a 9-month lifestyle intervention study examining the relationship between salivary AMY1 gene copy number, BMI z-score, and dietary intake. Intervention Parent-based support lifestyle intervention designed to improve children’s nutrition and reduce BMI through behavioral and dietary modifications. Comparison Standard care group…