Summary: In older adults aged 65–85 with overweight or obesity, the MIND diet significantly improved global cognitive scores compared to a control diet, though it was associated with no reported adverse effects. The effect was significant only among individuals with a body mass index (BMI) ≥ 35 kg/m2. PICO Description Population Community-dwelling older adults aged 65–85 years with overweight or obesity (mean BMI = 33.9 kg/m²); N = 604. Intervention The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet over multiple years, assessing annual cognitive change. Comparison Control diet in a randomized trial setting, matched for calorie content and frequency of…
Author: FWA
Summary: In children and adolescents with type 1 diabetes using continuous glucose monitoring (CGM), an intensive, integrated weekly telehealth intervention significantly improved glycemic control (reduced HbA1c and enhanced time in range) compared to standard care with multiple daily insulin injections (MDIs), though it was associated with increased patient and caregiver engagement demands but no significant adverse effects. PICO Description Population Children and adolescents with type 1 diabetes using FreeStyle Libre 2 continuous glucose monitoring (CGM) and multiple daily insulin injections (MDIs). Intervention Intensive, integrated telehealth intervention involving weekly remote monitoring and personalized feedback over 12 weeks. Comparison Standard diabetes care…
Summary: In people with diabetes attending urban primary healthcare follow-up, family-centered training and counselling intervention significantly improved foot self-care knowledge, practice, and family support compared to standard care without family-based education, though it was associated with no reported adverse side effects. PICO Description Population Adults aged 18–60 years with diabetes mellitus and their family members (2 per patient), receiving follow-up care at a primary urban health center in Jodhpur, India. Intervention Family-centered training and counselling on diabetic foot care, aimed at improving patient knowledge, practices, and family involvement in self-care routines. Comparison Standard diabetes follow-up care without the addition of…
Summary: In persons with diabetes attending urban primary care settings, family-centered training and counselling significantly improved foot self-care knowledge and practices compared to standard care without family-centered interventions, though it was associated with no significant adverse effects reported. PICO Description Population Persons with diabetes attending urban primary care clinics in Jodhpur, India. Intervention Family-centered training and counselling focused on foot self-care knowledge and preventive practices. Comparison Usual care without structured family-centered training or counselling on foot care. Outcome Significant improvement in foot self-care knowledge and practices in the intervention group compared to control; no major adverse effects reported. Source: Rehana…
Summary: In patients with diabetic neuropathic pain (DNP), non-invasive peripheral nerve neuromodulation (NipRF therapy) significantly reduced neuropathic pain symptoms compared to placebo/sham treatment, though it was associated with minimal adverse events and was well tolerated. PICO Description Population Adults diagnosed with diabetic neuropathic pain (DNP), experiencing chronic peripheral neuropathic symptoms related to diabetes mellitus. Intervention Non-invasive peripheral nerve radiofrequency (NipRF) neuromodulation therapy administered according to the study protocol. Comparison Placebo or sham treatment without active neuromodulation. Outcome NipRF therapy significantly reduced neuropathic pain scores compared to placebo, with improved functional outcomes and quality of life. The intervention demonstrated a favorable…
Summary: In elderly individuals with type 2 diabetes mellitus, the pharmacist-led SUGAR Handshake educational intervention significantly improved adherence to hypoglycaemia-prevention practices and participant engagement compared to usual outpatient care, though it was associated with implementation challenges including age-related conditions, declining health, and psychological stress. PICO Description Population Elderly adults with type 2 diabetes mellitus attending outpatient clinics in a Jordanian hospital. Intervention The SUGAR Handshake – a pharmacist-led educational program designed to prevent hypoglycaemia through counselling, diary usage, and self-monitoring of blood glucose. Comparison Usual care received at the outpatient clinic without structured pharmacist-led education. Outcome High intervention fidelity (98.11%…
Summary: In elderly people with type 2 diabetes at risk of hypoglycaemia, the SUGAR Handshake intervention significantly improved hypoglycaemia prevention and patient adherence compared to usual care or no specific intervention, though it was associated with implementation barriers requiring further educational support. PICO Description Population Elderly individuals with type 2 diabetes at risk of hypoglycaemia participating in a pragmatic randomized controlled trial. Intervention The SUGAR Handshake educational intervention aiming to prevent hypoglycaemia through behavioral support and patient-provider communication. Comparison Usual diabetes care without the SUGAR Handshake intervention. Outcome The intervention enhanced adherence to hypoglycaemia management protocols and patient outcomes but…
Summary: In patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), anticoagulation with bivalirudin followed by a prolonged high-dose infusion significantly reduced the risk of all-cause death or major bleeding compared to heparin monotherapy in patients with lower BMI (< 25 kg/m2), though it was associated with no additional benefit in patients with BMI ≥ 25 kg/m2. PICO Description Population 6,016 adults with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI, stratified by BMI (< 25 kg/m2 vs. ≥ 25 kg/m2), predominantly via radial access. Intervention Procedural anticoagulation with bivalirudin followed by a prolonged high-dose infusion…
Summary: In patients with type 2 diabetes and Wagner grade 1-2 diabetic foot ulcers (DFUs), daily topical application of ozonated olive oil (50 g/m³, 5 mL for 4 weeks) significantly improved wound healing, quality of life, glycemic control (HbA1c, FBG, PPG), and lowered hs-CRP inflammation marker compared to standard wound care, though it was associated with no reported adverse side effects. PICO Description Population Adults aged 18–75 years with type 2 diabetes and Wagner grade 1–2 diabetic foot ulcers treated in a tertiary care center. Intervention Daily topical ozonated olive oil (50 g/m³ concentration, 5 mL per application) over 4…
Summary: In trained adult athletes, short-term low energy availability (LEA; 15 kcal·kg FFM⁻¹·day⁻¹) significantly altered the serum metabolome towards increased fat utilization, enhanced ketogenesis, and reduced circulating triglycerides and amino acids compared to high energy availability (HEA; 40 kcal·kg FFM⁻¹·day⁻¹), achieved with or without exercise, though it was associated with no reported adverse effects in this short-term trial. PICO Description Population Trained adult individuals participating in two randomized controlled trials focused on energy availability levels. Intervention Short-term exposure (3–5 days) to low energy availability (LEA) at 15 kcal·kg FFM⁻¹·day⁻¹, with and without daily aerobic exercise. Comparison High energy availability (HEA)…