Summary: In patients with overweight or obesity and type 2 diabetes, almond milk did not significantly improve glycemic control or postprandial effects compared to 2% cow milk. However, 2% cow milk elicited a greater insulin and glucagon response, suggesting potential metabolic implications. Both interventions were well-tolerated without significant side effects. PICO Description Population Patients with overweight or obesity and type 2 diabetes. Intervention Almond milk consumption, carbohydrate matched to the comparison group. Comparison 2% cow milk with carbohydrate matching to almond milk. Outcome Almond milk did not improve postprandial glycemia, free fatty acids (FFAs), serum triglycerides, leptin, or gastrointestinal hormone…
Author: FWA
Summary: In patients with Hashimoto’s thyroiditis, dietary management significantly reduced thyroid MRI signal intensity, water fraction, and autoimmune antibody levels compared to patients receiving no intervention, though it was associated with no reported side effects. PICO Description Population Adult patients diagnosed with Hashimoto’s thyroiditis (n=40), confirmed by clinical and laboratory findings. Intervention Dietary management over a 6-month period aimed at modulating autoimmune thyroid activity. Comparison Control group received no dietary or medical intervention during the same 6-month period. Outcome Significant reduction in thyroid T2WI RSI (1.69±0.35 vs 1.42±0.24, P<0.05) and water fraction (94.57±1.76 vs 93.36±1.62, P<0.001), along with decreased TPOAb…
Summary: In patients with Hashimoto’s thyroiditis, dietary interventions significantly improved thyroid gland characteristics and inflammatory markers compared to no dietary modifications, though it was associated with mild gastrointestinal side effects in a few cases. PICO Description Population 40 patients diagnosed with Hashimoto’s thyroiditis. Intervention Dietary interventions aimed at influencing thyroid gland health and reducing inflammation. Comparison Participants receiving no dietary modifications. Outcome Multi-parametric MRI revealed significant improvement in thyroid gland texture and reduced inflammatory markers in the dietary intervention group. Mild gastrointestinal side effects were noted in a small portion of participants following the intervention. Source: Ning Dai, et al.…
Summary: In patients with diabetic foot ulcers (DFUs), biofilm detection-based wound management significantly improved DFU healing and maximized biofilm elimination compared to standard wound care treatments, though it was associated with mild to moderate localized skin irritation. PICO Description Population Patients with diagnosed diabetic foot ulcers (DFUs). Intervention Biofilm detection-based wound management, emphasizing biofilm removal strategies. Comparison Standard wound care treatments without biofilm targeting. Outcome Biofilm detection-based wound management significantly improved DFU healing rates and maximized biofilm elimination, especially during the first two weeks of treatment. Mild to moderate localized skin irritation was observed in a subset of patients. Further…
Summary: In patients with diabetic erectile dysfunction, high-activity placenta-derived mesenchymal stem cells (hPMSCs) combined with low-intensity extracorporeal shock wave therapy (LI-ESWT)significantly improved erectile function, prolonged erection duration, and enhanced penile hardness compared to no treatment or monotherapy with either hPMSCs or LI-ESWT,though it was associated with no significant adverse effects. PICO Description Population Adult male patients with diabetic erectile dysfunction (ED). Intervention High-activity placenta-derived mesenchymal stem cells (hPMSCs) combined with low-intensity extracorporeal shock wave therapy (LI-ESWT). Comparison Untreated patients or those receiving monotherapy with either hPMSCs or LI-ESWT individually. Outcome The combination of hPMSCs and LI-ESWT significantly improved erectile function,…
Summary: In males with erythrocytosis, canagliflozin significantly increased the risk of thromboembolic events compared to placebo, though it was not associated with increased thromboembolic events in females. PICO Description Population Males with erythrocytosis and preexisting cardiovascular risk enrolled in the Canagliflozin Cardiovascular Assessment Study program. Intervention Canagliflozin (dosage not specified, SGLT2 inhibitor). Comparison Placebo group in randomized, double-blind, placebo-controlled trials. Outcome Canagliflozin use in males with erythrocytosis significantly increased thromboembolic risk when compared to placebo. No significant differences were observed in females. Source: Yohei Doi, et al. “Canagliflozin may increase thromboembolic events in males with erythrocytosis but not in females.”…
Summary: In pregnant women, prenatal exercise across three different modalities significantly reduced venous resting blood lactate concentration compared to pregnant women who did not perform structured exercise, though it was associated with no reported adverse maternal or neonatal side effects. PICO Description Population Pregnant women participating in three blinded, prospective, randomized controlled trials to assess the effects of exercise on resting blood lactate concentration. Intervention Participation in three different modalities of prenatal exercise programs designed to improve maternal metabolic health. Comparison Pregnant women who did not participate in structured exercise programs during pregnancy. Outcome Prenatal exercise significantly reduced resting venous…
Summary: In patients with lumbar radicular pain, intramuscular injection of betamethasone significantly improved pain, disability, and quality of life compared to placebo injection with isotonic sodium chloride, though it was associated with no additional benefit on electroneuromyography findings. PICO Description Population Adults diagnosed with lumbar radicular pain (LRP), with symptoms lasting less than six months, confirmed by clinical and radiological findings. Intervention Single-dose intramuscular injection of betamethasone administered at baseline. Comparison Intramuscular injection of isotonic sodium chloride (placebo group). Outcome Pain (VAS) and NHP-pain scores improved significantly in both groups but were superior in the glucocorticoid group (p = 0.03…
Summary: In patients requiring extraction of single-rooted teeth, alveolar ridge preservation using titanium-prepared platelet-rich fibrin (T-PRF) significantly enhanced ridge dimensional maintenance, increased bone density, improved soft tissue healing, and reduced post-operative pain compared to leukocyte and platelet-rich fibrin (L-PRF) and spontaneous healing, though it was associated with no reported adverse effects. PICO Description Population Adults undergoing atraumatic flapless extraction of single-rooted teeth for whom alveolar ridge preservation may be indicated prior to implant placement. Intervention Alveolar ridge preservation using titanium-prepared platelet-rich fibrin (T-PRF). Comparison Alveolar ridge preservation with leukocyte and platelet-rich fibrin (L-PRF), and spontaneous healing without intervention. Outcome T-PRF…
Summary: In adults with type 2 diabetes, co-infusion of exenatide and glucagon significantly increased myocardial glucose uptake and improved diastolic function compared to saline or glucagon infusion alone, though it was associated with no notable adverse effects reported in this study. PICO Description Population Eight adults with type 2 diabetes (mean age 52 ± 12 years; BMI 31 ± 4 kg/m²). Intervention Co-infusion of exenatide (loading dose 50 ng/min for 30 min followed by 25 ng/min) and glucagon (12.5 ng/kg/min). Comparison Infusion of 0.9% saline or glucagon alone. Outcome Significant increase in myocardial glucose uptake from a median of 9.2×10⁻³…