Summary: In patients with obesity and osteoarthritis awaiting hip or knee joint replacement, a self-management support programme (Flinders Program) in addition to usual care significantly improved social support and social activity-related quality of life outcomes compared to usual care alone, though it was associated with no reported adverse effects. PICO Description Population Adults with obesity and osteoarthritis who were awaiting hip or knee arthroplasty. Intervention The Flinders Program of self-management support in combination with usual care. Comparison Usual care alone without the structured self-management programme. Outcome No significant difference in SF-36 health survey scores, but patients receiving the intervention showed…
Author: FWA
Summary: In patients undergoing elective transsphenoidal surgery for pituitary adenoma, a pure endoscopic approach significantly reduced the risk of tumor recurrence and enhanced long-term achievement of surgical goals and anterior pituitary function compared to an endoscope-assisted microscopic technique, though it was associated with similar complication rates and no increase in hospital stay or other morbidities. PICO Description Population Patients (n=33) undergoing elective transsphenoidal surgery for pituitary adenoma. Intervention Pure endoscopic transsphenoidal surgery for pituitary adenoma resection. Comparison Endoscope-assisted microscopic transsphenoidal surgery. Outcome Endoscopic surgery resulted in lower risk of tumor recurrence (OR = 0.24), better long-term achievement of surgical goals…
Summary: In patients undergoing laparoscopic sleeve gastrectomy (LSG), preoperative assessment using a combination of HDL-c levels and visceral adipose tissue (VAT) significantly predicted postoperative VAT reduction compared to assessment based solely on individual macroscopic anthropometric or metabolic parameters, though it was associated with no reported adverse effects. PICO Description Population Adults undergoing laparoscopic sleeve gastrectomy (LSG) for obesity-related metabolic disorders. Intervention Use of a predictive nomogram based on preoperative HDL-c levels and visceral adipose tissue (VAT) to assess VAT reduction outcomes post-LSG. Comparison Standard preoperative assessments relying only on general anthropometric and metabolic measurements, without combined biomarker modeling. Outcome The…
Summary: In families of individuals with premature coronary heart disease, a family-based structured lifestyle modification intervention significantly improved quality-adjusted life years (QALYs) and reduced key cardiovascular risk factors compared to usual care involving one-time counselling and annual screening, though it was associated with modest incremental costs. PICO Description Population Adults (>18 years), including first-degree relatives and spouses of individuals with premature coronary heart disease. Intervention A comprehensive package of structured lifestyle interventions including risk factor screening, behavior change support by non-physician health workers, linkage to primary care, and active follow-up over two years. Comparison Usual care consisting of one-time lifestyle…
Summary: In sedentary adults with metabolic syndrome, reducing sedentary time by at least 30 minutes daily through increased standing and light physical activity significantly improved metabolic flexibility and fat oxidation during low-intensity exercise compared to maintained sedentary behavior, though it was associated with no reported adverse effects. PICO Description Population Sedentary adults diagnosed with metabolic syndrome (n = 64). Intervention Intervention group (n = 33) reduced sedentary time by approximately 41 minutes/day through increased standing and non-exercise physical activity over a 6-month period, measured via accelerometry. Comparison Control group (n = 31) maintained baseline sedentary behavior without intervention. Outcome Among…
Summary: In patients with diabetes mellitus-induced erectile dysfunction (DMED) and Qi deficiency with blood stasis syndrome, moxibustion combined with low-dose tadalafil (5 mg daily) significantly improved erectile function, penile hemodynamics, and TCM symptom scores compared to moxibustion alone or tadalafil alone, though it was associated with no significant adverse effects. PICO Description Population Ninety male patients diagnosed with diabetes mellitus-induced erectile dysfunction (DMED) and presenting with Qi deficiency and blood stasis syndrome. Intervention Combined therapy of mild moxibustion at acupoints (Zusanli, Sanyinjiao, Yinlingquan) every other day and daily oral administration of 5 mg tadalafil for 4 weeks. Comparison Moxibustion alone…
Summary: In patients with type-II diabetes mellitus (DM) with qi-yin deficiency complicated by asthenospermia, Wuziyuye Decoction significantly improved sperm progressive motility, sperm concentration, and traditional Chinese medicine (TCM) syndrome scores compared to oral L-carnitine solution (control), both in combination with standard glucose-lowering therapy, though it was associated with no severe adverse reactions. PICO Description Population Male patients diagnosed with type-II diabetes mellitus with qi-yin deficiency syndrome and asthenospermia (n = 100), aged and clinically evaluated at the First Hospital Affiliated to Ningbo University from January 2023 to March 2024. Intervention Wuziyuye Decoction administered orally for 12 weeks alongside standard Western…
Summary: In healthy adults, intradermal morphine significantly induced itch and increased neurogenic inflammation compared to controls (placebo and mechanical stimulation), though it was associated with mild localized discomfort. PICO Description Population Twenty-four healthy adult volunteers. Intervention Intradermal injection of morphine to the volar forearm. Comparison Placebo injection and experimental mechanical stimulation. Outcome Intradermal morphine induced significant itch with histaminergic and non-histaminergic components, along with increased neurogenic inflammation. Responses to induced itch were enhanced, though mild discomfort was reported at the injection site. Source: Lo Vecchio, Silvia, et al. “Effect of Intradermal Morphine on Histaminergic and Non-Histaminergic Itch: A Randomised, Single-Blinded,…
Summary: In infants born to mothers supplemented with DHA during pregnancy, prenatal DHA supplementation at 800 mg daily significantly improved markers of visual attention and showed faster visual learning compared to a lower dose (200 mg daily) and placebo groups, though it was associated with no reported adverse effects. PICO Description Population Infants at 4 and 6 months of age born to mothers who participated in a prenatal DHA supplementation clinical trial. Intervention Daily prenatal supplementation with 800 mg of docosahexaenoic acid (DHA). Comparison Daily prenatal supplementation with 200 mg DHA or placebo. Outcome Infants whose mothers received 800 mg/day…
Summary: In patients with type-II diabetes mellitus (DM) with qi-yin deficiency complicated by asthenospermia Wuziyuye Decoction significantly improved sperm motility and concentration compared to the control group, though it was associated with no significant side effects. PICO Description Population Patients with type-II diabetes mellitus (DM) characterized by qi-yin deficiency and complicated by asthenospermia. Intervention Wuziyuye Decoction (specific traditional Chinese herbal formula). Comparison Control group receiving routine care or any alternative treatment. Outcome Wuziyuye Decoction resulted in significant improvements in sperm motility and concentration. It was also deemed safe, with no notable side effects reported. Source: Yu, Yi, et al. “Wuziyuye…