Structured Summary: In Japanese patients with type 2 diabetes, having a history of treatment dropout and HbA1c levels ≥10% significantly increased the risk of subsequent dropout compared to patients without a treatment dropout history or lower HbA1c levels, though it was associated with no major clinical safety concerns. PICO Description Population Japanese patients with type 2 diabetes who participated in the J-DOIT2-LT008 trial. Intervention Patients with a history of treatment dropout and HbA1c levels of ≥10%. Comparison Patients without a history of dropout and HbA1c levels under 10%. Outcome A history of treatment dropout was strongly associated with a higher…
Author: FWA
Summary: In patients with type 2 diabetes from the EXSCEL trial, once-weekly GLP-1 receptor agonist exenatide significantly reduced all-cause mortality (ACM) risk compared to conventional cardiovascular (CV) risk factor changes, though it was associated with modest effects on hospitalization for heart failure (hHF) and myocardial infarction (MI). PICO Description Population Adult patients with type 2 diabetes from the EXSCEL trial. Intervention Once-weekly GLP-1 receptor agonist exenatide. Comparison Conventional CV risk factor changes induced over 1-year. Outcome Exenatide significantly reduced ACM risk. However, observed changes in CV risk factors explained only a moderate proportion of the observed impact on specific outcomes…
Summary: In patients with type-II diabetes mellitus (DM) with qi-yin deficiency complicated by Asthenospermia, Wuziyuye Decoction significantly improved sperm motility and sperm concentration compared to conventional treatment, though it was associated with no significant adverse effects. PICO Description Population Patients diagnosed with type-II DM and qi-yin deficiency complicated by asthenospermia. Intervention Wuziyuye Decoction. Comparison Conventional treatment for type-II DM and associated complications. Outcome Wuziyuye Decoction improved sperm motility and concentration effectively in patients while showing no significant adverse effects, indicating its safety and efficacy. Source: Yi Yu, et al. “Wuziyuye Decoction for type-II diabetes mellitus with qi-yin deficiency complicated by…
Summary: In diabetes mellitus-induced erectile dysfunction (DMED) patients, moxibustion combined with low-dose tadalafil significantly improved erectile function compared to low-dose tadalafil alone and moxibustion alone, though it was associated with minor transient side effects. PICO Description Population Male patients with diabetes mellitus-induced erectile dysfunction (DMED). Intervention Combination of moxibustion therapy and low-dose tadalafil. Comparison Low-dose tadalafil alone and moxibustion alone. Outcome The combination of moxibustion and tadalafil significantly improved erectile function by enhancing penile blood supply, benefiting qi, and activating blood circulation, with minor transient side effects reported. Source: Tao Liu, et al. “Moxibustion combined with low-dose tadalafil for diabetes…
Summary: In patients with type 2 diabetes, the for Diabetes mobile app for self-management significantly increased the perception of the disease as more threatening compared to baseline perceptions before use. PICO Description Population Adults diagnosed with type 2 diabetes (43 participants). Intervention Use of the forDiabetes mobile app for self-management over a period of four weeks. Comparison Baseline perceptions of the disease before starting the intervention. Outcome Participants perceived their disease as more threatening after four weeks of using the mobile app. This was determined through disease perception assessments conducted through questionnaires. Source: Gosak, Lucija, et al. “How Does Mobile…
Summary: In patients with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD) risk, Curcumin supplementation significantly improved clinical outcomes including glycemic control, lipid profile, and reduced ASCVD risk compared to placebo treatment, though it was associated with mild gastrointestinal discomfort in some patients. PICO Description Population Patients with type 2 diabetes mellitus (T2DM) and an atherosclerotic cardiovascular disease (ASCVD) risk score of ≥ 5%. Intervention Curcumin supplementation alongside standard diabetes management therapy. Comparison Placebo treatment alongside standard diabetes management therapy. Outcome Curcumin supplementation significantly reduced HbA1c levels, improved lipid profiles (e.g., lowered LDL and triglycerides), and decreased ASCVD…
Summary: In patients with periodontitis and type 2 diabetes mellitus (T2DM), periodontal therapy significantly improved clinical parameters such as probing depth (PD), clinical attachment level (CAL), and plaque index (PI) compared to patients with higher baseline markers of PD, CAL, PI, or HbA1c levels, though it was associated with the need to carefully consider nine baseline factors for optimal predictability in therapy outcomes. PICO Description Population Patients with type 2 diabetes mellitus (T2DM) and periodontitis. Intervention Periodontal therapy considering baseline factors (such as PD, CAL, PI, HbA1c, and more). Comparison Patients with higher baseline levels of PD, CAL, PI, or…
Summary: In individuals with alcohol use disorder (AUD), treatment with the GLP-1 receptor agonist exenatide did not significantly impact pro-inflammatory and metabolic biomarkers compared to a placebo group, and it was not associated with any notable adverse side effects. PICO Description Population Individuals diagnosed with alcohol use disorder (AUD). Intervention Treatment with the GLP-1 receptor agonist exenatide. Comparison Placebo group receiving no active treatment. Outcome No significant effect of exenatide on pro-inflammatory and metabolic biomarkers compared to placebo. No notable adverse side effects were observed. Source: Hviid, Malthe E B, et al. “Effect of the GLP-1 receptor agonist exenatide on…
Summary: In participants with type 1 diabetes (T1D), MBX-2982, a GPR119 agonist significantly augmented glucagon counterregulatory responses to hypoglycemia compared to placebo, though it was associated with nausea in some participants. PICO Description Population Adults aged 20–60 years with type 1 diabetes (T1D). Intervention MBX-2982, a GPR119 agonist. Comparison Placebo administered in a double-masked, crossover design. Outcome MBX-2982 significantly augmented glucagon counterregulatory responses to experimental hypoglycemia versus placebo. Some participants reported nausea, but no severe adverse events were observed. Source: Anika Bilal, et al. “A Randomized Controlled, Double-Masked, Crossover Study of a GPR119 Agonist on Glucagon Counterregulation During Hypoglycemia in…
Summary: In pregnant individuals categorized by metabolic health status (metabolically unhealthy obese – MUO vs. metabolically healthy obese – MHO), intensive behavioral therapy (IBT) for gestational weight gain (GWG) significantly reduced GWG in the MUO group compared to the MHO group, though it was associated with a higher incidence of gestational diabetes and increased infant adiposity in the MUO group. PICO Description Population Pregnant individuals classified as metabolically unhealthy obese (MUO) versus metabolically healthy obese (MHO). Intervention Intensive behavioral therapy (IBT) targeting gestational weight gain (GWG). Comparison Outcomes assessed between the MUO group and the MHO group during pregnancy. Outcome…