Summary: In patients with diabetic nephropathy (DN), a structured nutritional intervention combined with dapagliflozin significantly enhanced glycaemic control, renal function, nutritional status, and quality of life compared to dapagliflozin alone (10 mg/day) or conventional care, though it was associated with no significant difference in adverse event rates. PICO Description Population Adults (n=108) diagnosed with diabetic nephropathy (DN). Intervention Dapagliflozin 10 mg/day combined with a structured Mediterranean diet and oral nutritional supplements. Comparison Dapagliflozin 10 mg/day alone or conventional care without dapagliflozin or nutritional intervention. Outcome The group receiving nutritional intervention plus dapagliflozin showed superior improvements in HbA1c (-1.5% vs -0.9%),…
Author: FWA
Summary: In overweight and obese adults (BMI ≥ 23 kg/m2), the combination of high-intensity interval training (HIIT) and asparagus root extract (ARE) supplementation significantly improved oxidative stress markers, inflammation, and lipid metabolism compared to control, HIIT alone, or ARE alone groups (ARE dose: 1.71 ± 0.24 mg/kg/day of 20-hydroxyecdysone), though it was associated with a rise in malondialdehyde levels in the ARE-only group. PICO Description Population Seventy-two overweight or obese adults aged 18–30 years with a BMI ≥ 23 kg/m2. Intervention Combined intervention of high-intensity interval training (modified Tabata, 3x/week for 12 weeks at 80–90% and 40–50% maximal perceived exertion)…
Summary: In patients with type 2 diabetes mellitus (T2DM) suffering from diabetic foot (DF) or diabetic peripheral neuropathy (DPN), alprostadil intravenous injection (40 μg daily for 14–21 days, added to standard care) significantly improved clinical response rates and lipid metabolism compared to standard care alone without alprostadil, though it was associated with a low rate of mild adverse events (3.33%). PICO Description Population Adult patients with type 2 diabetes mellitus diagnosed with either diabetic foot (DF) or diabetic peripheral neuropathy (DPN). Intervention Alprostadil intravenous injection (40 μg/day) administered for 14 to 21 days in addition to standard diabetes care. Comparison…
Summary: In adults with diabetes undergoing telehealth insulin titration, bluetooth-enabled glucometers (BTG) did not demonstrate glycemic superiority but were associated with reduced emergency department visits compared to traditional glucometers (TG), though further studies are needed to assess long-term outcomes and cost-effectiveness. PICO Description Population Adults with diabetes receiving insulin titration via telehealth services. Intervention Use of bluetooth-enabled glucometers (BTG) for remote glucose monitoring during insulin titration. Comparison Use of traditional glucometers (TG) during telehealth insulin titration. Outcome No significant glycemic control difference between BTG and TG; however, BTG use was associated with fewer emergency department visits, indicating potential healthcare utilization…
Summary: In adolescents and young adults with type 1 diabetes, a 24-week low-carbohydrate (LC) or Mediterranean (MED) diet intervention significantly altered bone turnover markers (CTX and P1NP) compared to each other, though it was associated with variable effects on bone metabolism, indicating possible implications for bone health. PICO Description Population Adolescents and young adults aged 12-21 years diagnosed with type 1 diabetes. Intervention Low-carbohydrate diet or Mediterranean diet followed for 24 weeks. Comparison Comparison between low-carbohydrate diet group and Mediterranean diet group, each with 20 participants. Outcome Significant changes in bone turnover markers: C-terminal telopeptide (CTX) and procollagen type 1…
Summary: In psychiatric outpatients with diabetes, physician-led medication reviews through interdisciplinary dialogue significantly reduced the number of drugs and potentially inappropriate prescriptions (PIPs) compared to usual care without structured medication review, though it was associated with no significant differences in overall healthcare-related costs. PICO Description Population Forty-eight outpatients with severe mental disorders and comorbid diabetes receiving routine psychiatric care in Denmark. Intervention Physician-led medication reviews conducted through interdisciplinary dialogue involving psychiatrists and clinical pharmacologists. Comparison Standard care without structured medication review, reflecting usual clinical practice. Outcome The intervention group experienced a reduction in the median number of prescribed medications and…
Summary: In patients with type 2 diabetes experiencing cognitive decline, dapagliflozin and liraglutide treatment significantly improved neuroprotective outcomes compared to placebo or standard therapy, though it was associated with variable side effect profiles relevant to each drug. PICO Description Population Adults with type 2 diabetes experiencing cognitive decline associated with neural circuit dysfunction. Intervention Treatment with dapagliflozin or liraglutide administered at standard therapeutic doses. Comparison Placebo or standard therapy without neuroprotective agents. Outcome Liraglutide activated olfactory-related brain regions locally, while dapagliflozin enhanced functional integration within neural circuits, collectively demonstrating neuroprotective effects relevant to managing type 2 diabetes-related cognitive decline. Source:…
Summary: In individuals at risk for dementia with cardiometabolic features, intentional, non-pharmacological weight loss significantly reduced dementia risk as detected by a proteomic dementia risk test compared to no weight loss interventions, though it was associated with the usual challenges of sustained lifestyle modification. PICO Description Population Adults with cardiometabolic risk factors who are at increased risk for dementia. Intervention Intentional non-pharmacological weight loss achieved through lifestyle modifications such as diet and exercise. Comparison No weight loss intervention or usual care without targeted weight loss strategies. Outcome The proteomic dementia risk test demonstrated a significant reduction in estimated dementia risk…
Summary: In older adults with type 2 diabetes (T2D) and mild cognitive impairment (MCI), hyperbaric oxygen therapy (HBOT) did not significantly improve cognitive or brain imaging outcomes compared to sham treatment, though it was associated with a higher rate of serious adverse events (SAEs). PICO Description Population Older adults diagnosed with type 2 diabetes and mild cognitive impairment (MCI). Intervention Hyperbaric oxygen therapy (HBOT) administered over the study period (specific dosing regimen not detailed). Comparison Sham treatment serving as placebo control. Outcome No significant improvement in cognitive function or brain imaging outcomes with HBOT compared to sham; transient cognitive improvements…
Summary: In older adults at risk for type 2 diabetes, resistance exercise training significantly improved targeted cognitive function compared to controls with no structured resistance training, though it was associated with no major adverse effects reported. PICO Description Population Older adults identified as being at risk for type 2 diabetes, without established diabetes diagnosis. Intervention Structured resistance exercise training program targeting cognitive function improvements. Comparison Control groups without resistance training or with usual care routines. Outcome Resistance exercise yielded significant improvements in specific cognitive domains related to executive function. No major side effects were reported. The results suggest potential to…