Summary: In obese patients with type 2 diabetes mellitus and liver steatosis, curcumin supplementationsignificantly attenuated liver steatosis by reducing oxidative stress and inflammation compared to placebo, though it was associated with mild gastrointestinal side effects. PICO Description Population Obese adults diagnosed with type 2 diabetes mellitus presenting with liver steatosis. Intervention Curcumin supplementation administered over 12 months (exact dosing as per trial protocol). Comparison Placebo control group receiving no active curcumin treatment. Outcome Curcumin significantly reduced liver fat accumulation and markers of oxidative stress and inflammation compared to placebo. Mild gastrointestinal side effects were noted but no severe adverse events…
Author: FWA
Summary: In adults with type 2 diabetes mellitus (T2DM), Bifidobacterium animalis subsp. lactis TISTR 2591 (BA-2591) probiotic supplementation significantly improved glycemic control and immune response compared to placebo, though it was associated with mild gastrointestinal side effects. PICO Description Population Thai adults aged 35-65 years with type 2 diabetes mellitus receiving standard treatments. Intervention Bifidobacterium animalis subsp. lactis TISTR 2591 probiotic supplementation; dosing specifics as per study protocol. Comparison Placebo administered in a randomized, double-blind, placebo-controlled, crossover design. Outcome Significant improvements in glycemic control indicators and enhanced immune response; mild gastrointestinal side effects reported but no serious adverse events. Source:…
Summary: In women with type 2 diabetes, sitagliptin treatment significantly preserved total hip bone mineral density (T score) compared to placebo, though it was associated with no consistent effects on other bone sites or bone turnover markers. PICO Description Population Women diagnosed with type 2 diabetes mellitus. Intervention Sitagliptin administered at standard therapeutic dosing over the study period. Comparison Placebo treatment administered under identical conditions. Outcome Sitagliptin preserved total hip T score compared to placebo, indicating beneficial effects on bone mineral density at this site. No consistent changes were observed in other skeletal sites or bone turnover biomarkers. Findings suggest…
Summary: In patients with diabetic foot ulcers (DFUs), Wharton’s jelly mesenchymal stem cell-derived exosomes (MSC-Exos) significantly improved wound healing outcomes compared to standard wound care management, though it was associated with minimal adverse effects, which were generally well-tolerated. PICO Description Population Patients diagnosed with diabetic foot ulcers (DFUs) requiring advanced wound healing interventions. Intervention Application of Wharton’s jelly mesenchymal stem cell-derived exosomes (MSC-Exos) as a novel biological treatment promoting wound repair. Comparison Standard wound care regimens without MSC-Exos, including conventional dressings and routine management practices. Outcome MSC-Exos significantly enhanced wound closure rates and accelerated healing time compared to standard care.…
Summary: In diabetic patients undergoing off-pump coronary artery bypass grafting (OPCABG), intraoperative dexmedetomidine infusion at 0.5 µg/kg/h significantly reduced glucose variability, C-reactive protein (CRP) levels, and insulin requirements compared to saline placebo infusion, though it was associated with no significant difference in interleukin-6 (IL-6) levels and no major reported side effects. PICO Description Population Adult diabetic patients scheduled for off-pump coronary artery bypass grafting (OPCABG). Intervention Continuous intraoperative dexmedetomidine infusion at 0.5 µg/kg/h. Comparison Placebo group receiving equivalent volume of normal saline infusion. Outcome Dexmedetomidine significantly improved glucose variability (GV: 14.38 ± 3.45 vs. 16.44 ± 4.63, P = 0.042),…
Summary: In children and adolescents with suboptimally controlled type 1 diabetes using CGM and multiple daily insulin injections, intensified follow-up with weekly telehealth intervention significantly improved glycemic control, including reductions in HbA1c levels and improvements in CGM metrics compared to routine care without intensified telehealth, though it was associated with no significant adverse effects and did not alter time below range (TBR). PICO Description Population Children and adolescents (mean age 11.8 years) with type 1 diabetes of approximately 3.5 years duration, using FreeStyle Libre 2 CGM and multiple daily insulin injections. Participants had suboptimal glycemic control (mean HbA1c 9.4%). Intervention…
Summary: In patients with persistent and recalcitrant diabetic foot ulcers (DFUs),adjunctive treatment with a full-thickness decellularised placental membrane allograft (FT-DPM) significantly improved wound healing rates and ulcer closure compared to standard of care alone (debridement and moist wound therapy), though it was associated with some local adverse events including mild to moderate wound site irritation. PICO Description Population Adults with persistent and recalcitrant diabetic foot ulcers (DFUs) refractory to conventional treatment. Intervention Application of full-thickness decellularised placental membrane allograft (FT-DPM) to the wound bed post-debridement, left in place for 5-9 days. Comparison Standard of care (SoC) alone, including wound debridement…
Summary: In adults with prediabetes in primary care, a multifaceted digital intervention (PREDIABETEXT) did not significantly improve HbA1c levels compared to usual care, though it was associated with increased patient engagement. PICO Description Population Adults with prediabetes receiving primary care management. Intervention Multifaceted digital intervention consisting of personalized SMS messaging (PREDIABETEXT) aimed at lifestyle modification and diabetes prevention. Comparison Usual care without additional digital support. Outcome No significant improvement in HbA1c levels was observed. However, increased patient engagement was noted, suggesting potential benefits in adherence and behavioral change, warranting further research with more intensive interventions. Source: Sofía Mira-Martínez, et al.…
Summary: In adults at risk of type 2 diabetes, intermittent fasting plus early time-restricted eating (iTRE) and calorie restriction (CR) significantly reduced inflammatory markers such as CRP and TNF-α over six months compared to standard care (SC), though it was associated with no differential effects in adipose tissue gene expression or systemic inflammation between the interventions. PICO Description Population Adults (N = 209) with a mean BMI of 34.8 ± 4.7 kg/m² at risk of developing type 2 diabetes. Intervention Intermittent fasting with early time-restricted eating (iTRE): 30% energy intake between 08:00 and 12:00 on 3 days/week; and Calorie Restriction…
Summary: In adults at risk of type 2 diabetes with achieved weight loss, intermittent fasting combined with early time-restricted eating and calorie restriction significantly reduced systemic and adipose tissue markers of inflammation compared to control or other weight loss methods, though it was associated with no differential impact on inflammatory markers when weight loss exceeded median. PICO Description Population Adults at risk of type 2 diabetes undergoing weight loss interventions. Intervention Intermittent fasting combined with early time-restricted eating and calorie restriction. Comparison Control groups and other forms of weight loss interventions without intermittent fasting or time-restricted eating. Outcome Achieved weight…