Summary: In patients with heart failure with preserved ejection fraction (HFpEF), obesity, and with or without type 2 diabetes, tirzepatide (up to 15 mg weekly) significantly reduced the risk of cardiovascular death or worsening heart failure and improved clinical status and quality of life compared to placebo, though it was associated with slightly less weight loss in patients with type 2 diabetes. PICO Description Population Adults with heart failure with preserved ejection fraction (HFpEF) and a body mass index ≥30 kg/m², both with and without type 2 diabetes. Intervention Tirzepatide administered subcutaneously at doses up to 15 mg once weekly…
Author: FWA
Summary: In adults in China with uncontrolled type 2 diabetes (T2D) and comorbid cardiovascular disease (CVD) risk factors, a mobile message-based intervention (6 texts per week for 12 months) significantly improved glycemic control (HbA1c) and modestly lowered systolic blood pressure (SBP) compared to usual care alone, though it was associated with only modest net differences and no major side effects reported. PICO Description Population Adults with uncontrolled type 2 diabetes (mean HbA1c 10.2%) and cardiovascular risk factors, recruited from 5 clinical centers in China. Intervention Mobile message-based intervention involving 6 motivational and behavioral reminder texts per week over a period…
Summary: In patients with type 2 diabetes, enavogliflozin, a selective SGLT2 inhibitor significantly improved leptin levels, insulin resistance, and increased serum ketone levels compared to baseline or no enavogliflozin treatment, though it was associated with mild adverse effects related to metabolic parameters. PICO Description Population Adults with type 2 diabetes who were inadequately controlled and had elevated leptin and insulin resistance levels. Intervention Treatment with enavogliflozin, a selective sodium-glucose co-transporter-2 (SGLT2) inhibitor, over 24 weeks. Comparison Baseline metabolic and glycemic parameters or no enavogliflozin treatment. Outcome Enavogliflozin significantly decreased leptin levels independent of weight changes, improved insulin resistance, and increased…
Summary: In patients with type 2 diabetes (T2DM), dapagliflozin treatment over 4 years significantly improved coronary flow reserve (CFR) by 30% and reduced epicardial adipose tissue (EAT) thickness compared to placebo after treatment, though it was associated with no significant adverse cardiovascular effects. PICO Description Population Adults with type 2 diabetes mellitus (T2DM) at risk for cardiovascular diseases and undergoing treatment for at least 4 years. Intervention Dapagliflozin treatment given continuously over a 4-year period. Comparison Placebo treatment with additional intervention initiated after the 4-year period for comparisons. Outcome Dapagliflozin resulted in a 30% sustained improvement in coronary flow reserve…
Summary: In patients with ischemic heart disease (IHD), combination therapy of statins, SGLT2 inhibitors, and PCSK9 inhibitors significantly reduced lipid parameters (-74±10 mg/dL, p<0.05) compared to monotherapy groups (statins, SGLT2 inhibitors, PCSK9 inhibitors alone), though it was associated with minor modulation in response due to age and gender. PICO Description Population Adults (N=500) diagnosed with ischemic heart disease (IHD), enrolled from multiple centers for a 12-month randomized controlled trial. Intervention Combination therapy consisting of statins, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. Comparison Monotherapy groups receiving either statins alone, SGLT2 inhibitors alone, or PCSK9…
Summary: In women with gestational diabetes mellitus (GDM), a lifestyle intervention based on the medical internet of things significantly improved compliance and self-management, metabolic status (blood glucose and lipids), and pregnancy outcomes compared to usual care without the use of the medical internet of things, though it was associated with no reported significant side effects. PICO Description Population Women diagnosed with gestational diabetes mellitus (GDM). Intervention Lifestyle intervention incorporating the medical internet of things to enhance self-management and compliance. Comparison Usual care without the support of the medical internet of things. Outcome Improved compliance and effectiveness in self-management, better metabolic…
Summary: In pregnant women diagnosed with gestational diabetes mellitus (GDM), a lifestyle intervention based on the medical Internet of Things (mIoT) significantly improved glucose and lipid metabolic parameters, reduced maternal weight gain, and decreased adverse pregnancy outcomes compared to standard lifestyle interventions alone, though it was associated with no reported side effects. PICO Description Population Pregnant women diagnosed with gestational diabetes mellitus (GDM), enrolled in a randomized controlled trial (n=225). Intervention Lifestyle intervention delivered via a self-management model supported by the medical Internet of Things (mIoT), including digital monitoring and data feedback. Comparison Standard lifestyle intervention for GDM without the…
Summary: In healthy adults, protein-only intake significantly increased GLP-1 levels and urinary nitrogen excretion compared to carbohydrate-only intake, though it was associated with elevated nitrogen excretion over 24 hours. PICO Description Population Healthy adults. Intervention Protein-only ingestion. Comparison Carbohydrate-only ingestion. Outcome Protein-only ingestion significantly elevated GLP-1 levels, sustained for 240 minutes, and engaged an amino acid-mediated insulin response. It also significantly increased urinary nitrogen excretion, which persisted up to 24 hours. Carbohydrate-only intake resulted in significantly higher GIP levels and a larger immediate insulin response. Source: Matthieu Clauss, et al. “Effect of high intakes of protein-only and carbohydrate-only on plasma metabolites…
Summary: In patients with type 2 diabetes, lifestyle-based health promotion intervention significantly improved health behaviors and reduced irrational health beliefs and unhealthy eating behaviors compared to usual care with no intervention, though it was associated with no major side effects reported. PICO Description Population Patients with type 2 diabetes, aged 35-65, selected through convenience sampling, totaling 90 participants (45 in the experimental group and 45 in the control group). Intervention Eight 90-minute sessions of a lifestyle-based health promotion intervention focused on improving health behaviors, beliefs, and eating habits. Comparison Usual care with no structured intervention provided to the control group.…
Structured Summary: In Japanese patients with type 2 diabetes, having a history of treatment dropout and HbA1c levels ≥10% significantly increased the risk of subsequent dropout compared to patients without a treatment dropout history or lower HbA1c levels, though it was associated with no major clinical safety concerns. PICO Description Population Japanese patients with type 2 diabetes who participated in the J-DOIT2-LT008 trial. Intervention Patients with a history of treatment dropout and HbA1c levels of ≥10%. Comparison Patients without a history of dropout and HbA1c levels under 10%. Outcome A history of treatment dropout was strongly associated with a higher…