Summary: In patients with Charcot foot ulcers, pulsed electromagnetic field (PEMF) therapy significantly enhanced wound healing and bone regeneration compared to the standard of care, though it was associated with mild, localized discomfort at the application site in some cases. PICO Description Population Patients with Charcot foot ulcers, a complication often associated with neuropathy and diabetes. Intervention Pulsed electromagnetic field (PEMF) therapy applied adjunctively to traditional wound care management. Comparison Standard wound care alone without the addition of PEMF therapy. Outcome PEMF therapy significantly improved ulcer healing rates and promoted bone regeneration compared to standard care alone, with minimal side…
Author: FWA
Summary: In patients with mandibular Class II furcation defects, treatment with platelet rich fibrin matrix (PRFM) membrane combined with demineralized freeze-dried bone allograft (DFDBA) significantly enhanced clinical and radiographic outcomes compared to collagen membrane (Colo Gide) combined with DFDBA, though it was associated with no complete defect closure in either group. PICO Description Population 24 adult patients (15 males, 9 females) presenting with mandibular Class II furcation defects (buccal or lingual). Intervention Platelet rich fibrin matrix (PRFM) membrane used in combination with demineralized freeze-dried bone allograft (DFDBA). Comparison Collagen membrane (Colo Gide) used in combination with demineralized freeze-dried bone allograft…
Summary: In pregnant individuals with increased risk of gestational diabetes, time-restricted eating and exercise training before and during pregnancy did not significantly improve glycemic control compared to no structured dietary intervention or exercise program, and was not associated with specific adverse effects. PICO Description Population Pregnant individuals at increased risk of gestational diabetes. Intervention Time-restricted eating and exercise training implemented before and continued throughout pregnancy. Comparison No structured dietary or exercise intervention during pregnancy. Outcome No significant effect on glycemic control in late pregnancy was observed. There were no reported specific associated adverse effects. Source: Ma Jafar Sujan, et al.…
Summary: In adults with type 2 diabetes mellitus, Empagliflozin treatment significantly altered the plasma lipidome, identifying distinct lipid signatures compared to baseline lipid profiles observed at one and twelve weeks, though it was associated with potential subgroup-specific lipid profile changes. PICO Description Population Adults with type 2 diabetes mellitus. Intervention Empagliflozin treatment, administered over a period of 12 weeks. Comparison Baseline plasma lipidome profiles prior to Empagliflozin treatment. Outcome Empagliflozin-modulated plasma lipid profiles revealed distinct lipid signature changes at both week 1 and week 12. Five lipid changes were consistent across time points, and three of these showed directionally consistent…
Summary: In women with type 1 diabetes during pregnancy, metformin significantly reduced prandial insulin use and improved weight control compared to placebo, though it was associated with no significant effect on total insulin use. PICO Description Population Pregnant women with type 1 diabetes. Intervention Metformin as an adjunct for glycemic control. Comparison Placebo. Outcome Metformin was associated with reduced prandial insulin change and weight gain control, particularly in insulin-resistant subgroups. However, no impact was observed on total insulin change. These findings support further research on the role of metformin during pregnancy in type 1 diabetes. Source: Juuma, Elina, et al.…
Summary: In pregnant women with type 1 diabetes, metformin adjunct therapy significantly reduced prandial insulin requirements and improved weight gain control compared to placebo with standard insulin treatment, though it was associated with no adverse effects on glycaemic control or neonatal outcomes. PICO Description Population Pregnant women (n=126) with type 1 diabetes participating in a multicentre, randomised, double-blind, placebo-controlled study. Intervention Oral metformin administered alongside standard insulin therapy throughout pregnancy. Comparison Placebo administered alongside standard insulin therapy. Outcome While total insulin requirement change was not significantly different (33 IU vs. 27 IU; p = 0.193), prandial insulin increase was significantly…
Summary: In patients with diabetes who received drug-eluting stent (DES) implantation, indobufen-based dual antiplatelet therapy (DAPT) significantly reduced bleeding risk compared to aspirin-based DAPT, though it was associated with similar efficacy in preventing ischemic events. PICO Description Population Patients with diabetes undergoing drug-eluting stent (DES) implantation for coronary artery disease. Intervention Indobufen-based dual antiplatelet therapy (DAPT). Comparison Aspirin-based dual antiplatelet therapy (aspirin plus clopidogrel). Outcome Indobufen-based DAPT resulted in reduced bleeding risk compared to aspirin-based DAPT, with comparable levels of ischemic event prevention. Source: Shujing Wu, et al. “Indobufen Versus Aspirin Plus Clopidogrel in Patients After Coronary Stenting in Patients…
Summary: In emerging adults living with type 1 diabetes (T1D), a multicomponent, text message-based digital intervention significantly enhanced knowledge and motivation for self-management during the transition to adult care compared to standard care alone, though it was associated with varying responses among participant subgroups, highlighting the need for tailored approaches. PICO Description Population Emerging adults living with type 1 diabetes (T1D) transitioning to adult care. Intervention A multicomponent, text message-based digital intervention designed to enhance self-management knowledge and motivation. Comparison Standard care alone during the transition from pediatric to adult diabetes management. Outcome The digital intervention enhanced participants’ knowledge and…
Summary: In acute stroke patients with dysphagia, pharyngeal electrical stimulation significantly reduced dysphagia severity compared to sham treatment, though it was associated with no serious adverse effects. PICO Description Population Seventeen patients with acute ischemic or hemorrhagic stroke presenting with dysphagia (penetration-aspiration scale score 4–8 on videofluoroscopy). Intervention Pharyngeal electrical stimulation administered 10 minutes daily for 3 consecutive days. Comparison Sham stimulation (same schedule and procedure without therapeutic stimulus). Outcome Significant reduction in dysphagia severity by day 83 (difference: –4, p = 0.027), along with improvements in functional oral intake and diet/supervision subscales. No serious adverse events attributable to the…
Structured Summary: In patients with heart failure with preserved ejection fraction (HFpEF), obesity, and type 2 diabetes, tirzepatide significantly reduced the risk of adverse heart failure outcomes and improved health status, quality of life, and functional capacity compared to patients without diabetes, though it was associated with less pronounced weight loss compared to those without diabetes under similar interventions. PICO Description Population Adults with heart failure with preserved ejection fraction (HFpEF), obesity, and type 2 diabetes. Intervention Tirzepatide treatment aimed at reducing heart failure outcomes and improving health-related quality of life. Comparison Patients with HFpEF, obesity, but without diabetes undergoing…