Summary: In patients with clinically significant macular edema (CSME) in type 2 diabetes mellitus, low-dose atorvastatin (10-20 mg) as an adjunct to anti-VEGF therapy significantly improved functional anatomical outcomes compared to high-dose atorvastatin, though it was associated with minimal reported side effects. PICO Description Population Patients with clinically significant macular edema (CSME) in the context of type 2 diabetes mellitus. Intervention Low-dose atorvastatin (10-20 mg) used as an adjunct to anti-vascular endothelial growth factor (anti-VEGF) therapy. Comparison High-dose atorvastatin, also administered as an adjunct to anti-VEGF therapy. Outcome Low-dose atorvastatin resulted in better functional (improved vision outcomes) and anatomical outcomes…
Author: FWA
Structured Summary: In patients with diabetic macular edema, intravitreal aflibercept combined with dexamethasone phosphate significantly improved short-term structural and functional outcomes compared to intravitreal aflibercept alone, though it was associated with increased intraocular pressure as a main side effect. PICO Description Population Adults diagnosed with diabetic macular edema (DME). Intervention Combination therapy of intravitreal aflibercept and dexamethasone sodium phosphate. Comparison Intravitreal aflibercept monotherapy. Outcome The combination therapy resulted in improved short-term structural (retinal thickness) and functional (visual acuity) outcomes compared to aflibercept alone. However, it was associated with increased intraocular pressure. Source: Valesca Castro Neri, et al. “Intravitreal aflibercept alone…
Summary: In patients requiring posterior tooth extraction with immediate implant placement, chairside composite Sealing Socket Abutments (CS) significantly reduced volumetric tissue shrinkage compared to prefabricated zirconia abutments (ZR), though it was associated with increased probing depths. PICO Description Population Adults undergoing posterior tooth extraction with immediate implant placement using static computer-assisted implant surgery (sCAIS). Intervention Chairside-fabricated composite Sealing Socket Abutments (CS). Comparison Prefabricated zirconia Sealing Socket Abutments (ZR). Outcome Both groups exhibited stable Supra-Platform Tissue Height over 3 months. THT decreased significantly in both groups (CS: −1.00 mm, ZR: −1.17 mm), with less horizontal shrinkage in the CS group. Probing…
Summary: In patients with pituitary macroadenomas, gadobutrol significantly improved the evaluation of quantitative perfusion parameters compared to meglumine gadoterate, though it was associated with no significant differences in adverse effects. PICO Description Population Patients with pituitary macroadenomas undergoing dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Intervention Administration of gadobutrol, a macrocyclic non-ionic contrast agent, for DCE-MRI. Comparison Administration of meglumine gadoterate, a macrocyclic ionic contrast agent, for DCE-MRI. Outcome Gadobutrol enhanced the evaluation of pituitary macroadenoma perfusion parameters compared to meglumine gadoterate. No significant differences in adverse effects or safety profiles were observed between the two contrast agents. Source: Kihwan Hwang,…
Summary: In patients with type 2 diabetes and a history of prior stroke, intensive systolic blood pressure (SBP) control significantly reduced cardiovascular outcomes compared to standard SBP control, though it was associated with a higher rate of adverse events, including hypotension and electrolyte imbalances. PICO Description Population Patients with type 2 diabetes and a history of prior stroke enrolled in the ACCORD-BP trial. Intervention Intensive systolic blood pressure control targeting a systolic BP of <120 mmHg. Comparison Standard systolic blood pressure control targeting a systolic BP of <140 mmHg. Outcome Intensive SBP control significantly reduced major adverse cardiovascular events, but…
Summary: In patients with type 2 diabetes, the Diabetes Conversation Map™ program significantly improved knowledge retention, self-management behaviors, and self-efficacy compared to standard diabetes education, though it was associated with no notable adverse effects. PICO Description Population Adults with type 2 diabetes enrolled in outpatient diabetes clinics in Egypt. Intervention The Diabetes Conversation Map™ program, a Diabetes Self-Management Education and Support (DSMES) tool designed to improve patient knowledge and self-management. Comparison Standard diabetes education provided in the usual care setting. Outcome The Diabetes Conversation Map™ program led to significant enhancements in diabetes knowledge retention, improved self-management practices, and increased self-efficacy…
Summary: In patients with tennis elbow, kinesiotape, counterforce brace, and corticosteroid injection significantly reduced pain and tendon thickness compared to no treatment, though none of these methods proved superior to the others. PICO Description Population Patients diagnosed with tennis elbow. Intervention Kinesiotape application, counterforce bracing, or corticosteroid injections. Comparison Comparison among the three treatments and to no intervention. Outcome All three treatments significantly improved pain and reduced tendon thickness. However, none of the interventions demonstrated superiority over the others. Source: Seyyed Mohammadreza Hoseini, et al. “Comparison of kinesiotape, counterforce brace, and corticosteroid injection in patients with tennis elbow: A prospective,…
Summary: In patients with diabetic peripheral neuropathy (DPN), once-daily prolonged-release (PR) pregabalin significantly improved pain management compared to immediate-release (IR) pregabalin, though it was associated with similar adverse effects, including dizziness and somnolence. PICO Description Population Patients with diabetic peripheral neuropathy (DPN). Intervention Once-daily prolonged-release (PR) pregabalin. Comparison Immediate-release (IR) pregabalin. Outcome Both prolonged-release and immediate-release pregabalin demonstrated similar efficacy in managing pain associated with DPN. Both treatments were associated with comparable side effects, primarily dizziness and somnolence. Source: Shilpi Dhawan, et al. “Efficacy and Safety of Once-Daily Prolonged-Release Pregabalin for the Treatment of Patients With Diabetic Peripheral Neuropathy: A…
Structured Summary: In individuals with type 2 diabetes, cinnamon supplementation resulted in reductions in anthropometric measurements compared to a placebo group, though the differences were not statistically significant. PICO Description Population Adults with type 2 diabetes. Intervention Cinnamon supplementation. Comparison Placebo. Outcome Cinnamon supplementation resulted in reductions in anthropometric measurements (e.g., body weight, BMI). However, these differences were not statistically significant. Source: José Cláudio Garcia Lira Neto, et al. “Efficacy of cinnamon in reducing anthropometric measurements in individuals with type 2 diabetes: a clinical trial.” Read article here.
Summary: In type 2 diabetic patients with stage-II periodontitis, non-surgical periodontal therapy (PMPR) with adjunctive hyaluronic acid (HA) gel significantly improved HbA1c levels and clinical parameters of periodontitis compared to PMPR alone, though it was associated with no significant adverse effects reported. PICO Description Population Adults with type 2 diabetes and stage-II periodontitis. Intervention Non-surgical periodontal therapy (PMPR) with adjunctive hyaluronic acid (HA) gel application. Comparison Non-surgical periodontal therapy (PMPR) alone. Outcome Hyaluronic acid gel as an adjunct to PMPR significantly improved HbA1c levels and clinical outcomes for periodontitis compared to PMPR alone, with no notable adverse effects. Source: Reem…